The Changes of Serum-ACE, Plasma Renin Activity and Aldosterone in the Diabetics with Hypertension

1. The S-ACE activity was significantly elevated in 38 patients with diabetes mellitus (9.42±6.60 Unit) as compared with that in the healthy controls (2.53±1.54 Unit) (p<0.005) (p<0.005). 2. The S-ACE activity was significantly elevated in 15 hypertensive diabetics (14.29± 7.10 Unit) as compared with that in 23 normotensive diabetics (6.24±3.68 Unit) (p<0.005). 3. The S-ACE activity was elevated in 15 diabetic patients with retinopathy (10.6±4.7 Unit) as compared with the levels in 17 diabetic patients without retinopathy (6.7±4.8 U) (p<0.05). 4. The S-ACE activity was directly correlated to the mean arterial pressure (r=0.54) (p<0.005). 5. The plasma renin activity and aldosternone concentrations in diabetics were not different from the normal controls and had no correlationship to the S-ACE activity. 6. After 2 weeks of insulin therapy in 15 diabetics, the S-ACE activity was not changed.