Postprandial 2-hr C-peptide Concentration as a Guide for Insulin Treatment in Patient with NIDDM

To determine the usefulness of postpradial-2hr serum C-peptide as a guide for insulin treatment in NIDDM, the 67 NIDDM patients admitted in Kyung Hee University Hospital from Nov. 1981 to May 1984 were classified according to postprandial 2-hr insulin, C-peptide levels and 24-hr urine C-peptide levels. The patients were divided into 3 groups according to the level of insulin or C-peptide in normal persons reported previously.(9)) In 22 patients with postprandial 2-hr values of more than 5.8 ng/ml for C-peptide, 12 patients (55%) were diet controllable and only 5 patients (22%) required insulin treatment. On the other hand, in the classification according to postprandial 2-hr insulin or 24-hr urine C-peptide levels, higher response groups should be controlled by diet alone, but 9 of 18 patients (50%) for insulin, 8 of 14 patients (57%) for 24-hr urine C-peptide required insulin treatment. The classification according to postprandial 2hr C-peptide levels was a more sensitive guide for insulin treatment than that with postprandial 2hr insulin level or 24hr urine C-peptide level.