Changes of Plasma Angiotensin-Converting Enzyme Activity during Hemodialysis(*)

Plasma angiotensin-converting enzyme activity was measured by spectrophotometer in normal subjects and in patients with end stage renal failure, serially during a routine hemodialysis. Patients on maintenance hemodialysis tended to be associated with elevated plasma angiotensin-converting enzyme activity versus normal subjects. Plasma angiotensin-converting enzyme activity was significantly elevated in patients with chronic renal failure after 5 hours of hemodialysis(p<.001). Plasma angiotensin-converting enzyme activity corrected for hemoconcentration was also significantly increased(p<.05). There was a significant correlation between the increase in plasma angiotensin-converting enzyme activity after 5 hours of hemodialysis and the decrease in white blood cell count at one hour of hemodialysis (r = 0.51, p<.05). It is suggested that plasma angiotensin-converting enzyme analysis may prove to be a method for assessing transient pulmonary dysfunction during hemodialysis.