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Clonidine Induced Variations of Plasma Norepinephrine and Blood Pressure in Essential Hypertension

To assess the contribution of sympathetic outflow to blood pressure in patients with essential hypertension, clonidine induced variations of plasma norepinephrine, mean arterial pressure and the pulse rate three hours after a 300 μg dose of oral clonidine, an antihypertensive agent that decreases ce...

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Detalles Bibliográficos
Autores principales: Lee, Seung Sei, Kim, Hyang, Park, Young Chul, Song, Jun Ho, Lee, Man Ho, Chung, Eul Soon, Lee, Sang Jong, Imm, Chin Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 1987
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534933/
https://www.ncbi.nlm.nih.gov/pubmed/3154833
http://dx.doi.org/10.3904/kjim.1987.2.2.214
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author Lee, Seung Sei
Kim, Hyang
Park, Young Chul
Song, Jun Ho
Lee, Man Ho
Chung, Eul Soon
Lee, Sang Jong
Imm, Chin Woo
author_facet Lee, Seung Sei
Kim, Hyang
Park, Young Chul
Song, Jun Ho
Lee, Man Ho
Chung, Eul Soon
Lee, Sang Jong
Imm, Chin Woo
author_sort Lee, Seung Sei
collection PubMed
description To assess the contribution of sympathetic outflow to blood pressure in patients with essential hypertension, clonidine induced variations of plasma norepinephrine, mean arterial pressure and the pulse rate three hours after a 300 μg dose of oral clonidine, an antihypertensive agent that decreases central sympathetic outflow, were studied. Baseline and clonidine suppressed plasma norepinephrine levels were not significantly different between the normal controls and patients with essential hypertension. The average plasma norepinephrine level, mean arterial pressure and pulse rate were significantly decreased from the baseline value in both normal control and essential hypertension (p<.005). The depressor response to sympathetic inhibition after clonidine were exaggerated in significant proportion in patients with essential hypertension compared to normal control group. Our study suggests that the pressor sensitivity to norepinephrine plays more important role than sympathetic overactivity in some patients with essential hypertension.
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spelling pubmed-45349332015-10-02 Clonidine Induced Variations of Plasma Norepinephrine and Blood Pressure in Essential Hypertension Lee, Seung Sei Kim, Hyang Park, Young Chul Song, Jun Ho Lee, Man Ho Chung, Eul Soon Lee, Sang Jong Imm, Chin Woo Korean J Intern Med Articles To assess the contribution of sympathetic outflow to blood pressure in patients with essential hypertension, clonidine induced variations of plasma norepinephrine, mean arterial pressure and the pulse rate three hours after a 300 μg dose of oral clonidine, an antihypertensive agent that decreases central sympathetic outflow, were studied. Baseline and clonidine suppressed plasma norepinephrine levels were not significantly different between the normal controls and patients with essential hypertension. The average plasma norepinephrine level, mean arterial pressure and pulse rate were significantly decreased from the baseline value in both normal control and essential hypertension (p<.005). The depressor response to sympathetic inhibition after clonidine were exaggerated in significant proportion in patients with essential hypertension compared to normal control group. Our study suggests that the pressor sensitivity to norepinephrine plays more important role than sympathetic overactivity in some patients with essential hypertension. Korean Association of Internal Medicine 1987-07 /pmc/articles/PMC4534933/ /pubmed/3154833 http://dx.doi.org/10.3904/kjim.1987.2.2.214 Text en Copyright © 1987 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Lee, Seung Sei
Kim, Hyang
Park, Young Chul
Song, Jun Ho
Lee, Man Ho
Chung, Eul Soon
Lee, Sang Jong
Imm, Chin Woo
Clonidine Induced Variations of Plasma Norepinephrine and Blood Pressure in Essential Hypertension
title Clonidine Induced Variations of Plasma Norepinephrine and Blood Pressure in Essential Hypertension
title_full Clonidine Induced Variations of Plasma Norepinephrine and Blood Pressure in Essential Hypertension
title_fullStr Clonidine Induced Variations of Plasma Norepinephrine and Blood Pressure in Essential Hypertension
title_full_unstemmed Clonidine Induced Variations of Plasma Norepinephrine and Blood Pressure in Essential Hypertension
title_short Clonidine Induced Variations of Plasma Norepinephrine and Blood Pressure in Essential Hypertension
title_sort clonidine induced variations of plasma norepinephrine and blood pressure in essential hypertension
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534933/
https://www.ncbi.nlm.nih.gov/pubmed/3154833
http://dx.doi.org/10.3904/kjim.1987.2.2.214
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