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A Clinical and Chromosomal Study on Those Exposed to the Atomic Bomb and their Offspring

Presented in this paper is the data from clinical laboratory examination of 50 Korean atomic-bomb survivors (Hiroshima and Nagasaki, Japan, 1945). Of them, 15 survivors were karyotyped from their lymphocyte culture for both “stable” and “unstable” types of chromosomal aberrations. Eight of their off...

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Autores principales: Chung, Jung Myung, Choe, Ha Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 1987
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534936/
https://www.ncbi.nlm.nih.gov/pubmed/3154835
http://dx.doi.org/10.3904/kjim.1987.2.2.227
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author Chung, Jung Myung
Choe, Ha Jin
author_facet Chung, Jung Myung
Choe, Ha Jin
author_sort Chung, Jung Myung
collection PubMed
description Presented in this paper is the data from clinical laboratory examination of 50 Korean atomic-bomb survivors (Hiroshima and Nagasaki, Japan, 1945). Of them, 15 survivors were karyotyped from their lymphocyte culture for both “stable” and “unstable” types of chromosomal aberrations. Eight of their offspring were also tested for the chromosomal changes and SCE as well. 1. All survivors were found to have suffered from various diseases, particularly from respiratory diseases. Two had malignancies, viz., one case having squamous cell carcinoma of uterine cervix and another, adenocarcinoma of stomach. 2. Serum total protein and serum albumin levels were found to have decreased in 18% and 27% of the survivors, respectively. Alkaline phosphatase, SGOT, IgG and IgM increased in 22%, 6.3%, 36.7% and 13.6% of the survivors, respectively. IgA was within normal limit in all cases. 3. Stable type of chromosomal aberrations was discovered in none of the survivors and the offspring examined. However, approximtely 50% of the survivors showed a significantly higher incidence of chromatid breakage than normal controls. 4. None of the offspring showed the chromatid breakage, but 75% of them showed significantly higher rate of SCE when compared to controls.
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spelling pubmed-45349362015-10-02 A Clinical and Chromosomal Study on Those Exposed to the Atomic Bomb and their Offspring Chung, Jung Myung Choe, Ha Jin Korean J Intern Med Articles Presented in this paper is the data from clinical laboratory examination of 50 Korean atomic-bomb survivors (Hiroshima and Nagasaki, Japan, 1945). Of them, 15 survivors were karyotyped from their lymphocyte culture for both “stable” and “unstable” types of chromosomal aberrations. Eight of their offspring were also tested for the chromosomal changes and SCE as well. 1. All survivors were found to have suffered from various diseases, particularly from respiratory diseases. Two had malignancies, viz., one case having squamous cell carcinoma of uterine cervix and another, adenocarcinoma of stomach. 2. Serum total protein and serum albumin levels were found to have decreased in 18% and 27% of the survivors, respectively. Alkaline phosphatase, SGOT, IgG and IgM increased in 22%, 6.3%, 36.7% and 13.6% of the survivors, respectively. IgA was within normal limit in all cases. 3. Stable type of chromosomal aberrations was discovered in none of the survivors and the offspring examined. However, approximtely 50% of the survivors showed a significantly higher incidence of chromatid breakage than normal controls. 4. None of the offspring showed the chromatid breakage, but 75% of them showed significantly higher rate of SCE when compared to controls. Korean Association of Internal Medicine 1987-07 /pmc/articles/PMC4534936/ /pubmed/3154835 http://dx.doi.org/10.3904/kjim.1987.2.2.227 Text en Copyright © 1987 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Chung, Jung Myung
Choe, Ha Jin
A Clinical and Chromosomal Study on Those Exposed to the Atomic Bomb and their Offspring
title A Clinical and Chromosomal Study on Those Exposed to the Atomic Bomb and their Offspring
title_full A Clinical and Chromosomal Study on Those Exposed to the Atomic Bomb and their Offspring
title_fullStr A Clinical and Chromosomal Study on Those Exposed to the Atomic Bomb and their Offspring
title_full_unstemmed A Clinical and Chromosomal Study on Those Exposed to the Atomic Bomb and their Offspring
title_short A Clinical and Chromosomal Study on Those Exposed to the Atomic Bomb and their Offspring
title_sort clinical and chromosomal study on those exposed to the atomic bomb and their offspring
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534936/
https://www.ncbi.nlm.nih.gov/pubmed/3154835
http://dx.doi.org/10.3904/kjim.1987.2.2.227
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