HLA and Insulin-Dependent Diabetes Mellitus in Koreans()

Specific allelic associations vary among ethnic groups. We studied the distribution of HLA-A, -B, -C and -DR antigens in 41 patients with insulin-dependent diabetes mellitus (IDDM) and 280 unaffected persons in Korea. HLA typing was performed by the standard microlymphocytotoxicity test using antise...

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Detalles Bibliográficos
Autores principales: Rhee, Byoung Doo, Choi, Sang Jeon, Park, Sung Woo, Choi, Dong Seop, Han, Hoon, Kim, Geum Ryoung, Kim, Seong Yeon, Cho, Bo Youn, Lee, Hong Kyu, Koh, Chang-Soon, Min, Hun Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 1987
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534941/
https://www.ncbi.nlm.nih.gov/pubmed/3154825
http://dx.doi.org/10.3904/kjim.1987.2.2.135
Descripción
Sumario:Specific allelic associations vary among ethnic groups. We studied the distribution of HLA-A, -B, -C and -DR antigens in 41 patients with insulin-dependent diabetes mellitus (IDDM) and 280 unaffected persons in Korea. HLA typing was performed by the standard microlymphocytotoxicity test using antisera supplied by the Third Asia-Oceania Histocompatibility Workshop Conference (3rd AOHWC, 1986). There was no association between HLA-A, -B, or -C and IDDM. However, the frequencies of HLA-DR3 and HLA-DR4 were increased in the patients as compared with the controls (19.5% vs 4.3%, RR 5.4, corrected p < 0.005 for DR3 and 61.0% vs 36.4%, RR 2.7, corrected p < 0.05 for DR4). Also a decreased frequency of HLA-DR2 was found in the patients with IDDM (9.8% vs 32.1%, RR 0.3, corrected p < 0.05). These results emphasize the differences in HLA-IDDM associations among different ethnic groups.

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