A Virus Similar to Human Hepatitis B Virus in Manchurian Chipmunks

In searching for a new host of the hepadna virus, we found a virus with many of the unique properties of the human hepatitis B virus (HBV) in sera from Manchurian chipmunks inhabiting Korea. Of 192 tested animals, 8 chipmunks were found to have weak HBsAg reactivities and particles similar in size a...

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Autores principales: Yoo, Byung Chul, Park, Sil Moo, Kim, Chung Yong, Park, Hyo Sook, Seo, Jeong Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 1988
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534957/
https://www.ncbi.nlm.nih.gov/pubmed/3154186
http://dx.doi.org/10.3904/kjim.1988.3.2.102
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author Yoo, Byung Chul
Park, Sil Moo
Kim, Chung Yong
Park, Hyo Sook
Seo, Jeong Sun
author_facet Yoo, Byung Chul
Park, Sil Moo
Kim, Chung Yong
Park, Hyo Sook
Seo, Jeong Sun
author_sort Yoo, Byung Chul
collection PubMed
description In searching for a new host of the hepadna virus, we found a virus with many of the unique properties of the human hepatitis B virus (HBV) in sera from Manchurian chipmunks inhabiting Korea. Of 192 tested animals, 8 chipmunks were found to have weak HBsAg reactivities and particles similar in size and shape to the particles assoicated with HBV infection. The HBsAg-reactive particles contained DNA of similar size to that of HBV and a DNA polymerase activity which appeared to repair a single-stranded region of the DNA molecule. Histologic examination of liver tissues from chipmunks containing the viral particles in sera showed no evidence of liver disease. Experimental infection of chipmunk by inoculation of HBsAg-reactive chipmunks sera led to frequent occurence of acute and chronic hepatitis without antigenemia of HBsAg.
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spelling pubmed-45349572015-10-02 A Virus Similar to Human Hepatitis B Virus in Manchurian Chipmunks Yoo, Byung Chul Park, Sil Moo Kim, Chung Yong Park, Hyo Sook Seo, Jeong Sun Korean J Intern Med Original Article In searching for a new host of the hepadna virus, we found a virus with many of the unique properties of the human hepatitis B virus (HBV) in sera from Manchurian chipmunks inhabiting Korea. Of 192 tested animals, 8 chipmunks were found to have weak HBsAg reactivities and particles similar in size and shape to the particles assoicated with HBV infection. The HBsAg-reactive particles contained DNA of similar size to that of HBV and a DNA polymerase activity which appeared to repair a single-stranded region of the DNA molecule. Histologic examination of liver tissues from chipmunks containing the viral particles in sera showed no evidence of liver disease. Experimental infection of chipmunk by inoculation of HBsAg-reactive chipmunks sera led to frequent occurence of acute and chronic hepatitis without antigenemia of HBsAg. Korean Association of Internal Medicine 1988-07 /pmc/articles/PMC4534957/ /pubmed/3154186 http://dx.doi.org/10.3904/kjim.1988.3.2.102 Text en Copyright © 1988 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoo, Byung Chul
Park, Sil Moo
Kim, Chung Yong
Park, Hyo Sook
Seo, Jeong Sun
A Virus Similar to Human Hepatitis B Virus in Manchurian Chipmunks
title A Virus Similar to Human Hepatitis B Virus in Manchurian Chipmunks
title_full A Virus Similar to Human Hepatitis B Virus in Manchurian Chipmunks
title_fullStr A Virus Similar to Human Hepatitis B Virus in Manchurian Chipmunks
title_full_unstemmed A Virus Similar to Human Hepatitis B Virus in Manchurian Chipmunks
title_short A Virus Similar to Human Hepatitis B Virus in Manchurian Chipmunks
title_sort virus similar to human hepatitis b virus in manchurian chipmunks
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534957/
https://www.ncbi.nlm.nih.gov/pubmed/3154186
http://dx.doi.org/10.3904/kjim.1988.3.2.102
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