A Case of Methimazole-Induced Acute Hepatic Failure in A Patient With Chronic Hepatitis B Carrier

We report a case of methimazole-induced acute hepatic failure, which occurred 17 weeks after initiation of the drug in a 43-year-old man with hyperthyroidism and hepatitis B surface antigenemia. Postmortem needle autopsy of the liver revealed an established micronodular cirrhosis secondary to hepati...

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Autores principales: Kang, Hun, Choi, Jong Do, Jung, In Gu, Kim, Dong Whan, Kim, Tae Bin, Shin, Ho Kyun, Kim, Byung Tae, Park, Choong Kee, Yoo, Jae Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 1990
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535001/
https://www.ncbi.nlm.nih.gov/pubmed/2271514
http://dx.doi.org/10.3904/kjim.1990.5.1.69
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author Kang, Hun
Choi, Jong Do
Jung, In Gu
Kim, Dong Whan
Kim, Tae Bin
Shin, Ho Kyun
Kim, Byung Tae
Park, Choong Kee
Yoo, Jae Young
author_facet Kang, Hun
Choi, Jong Do
Jung, In Gu
Kim, Dong Whan
Kim, Tae Bin
Shin, Ho Kyun
Kim, Byung Tae
Park, Choong Kee
Yoo, Jae Young
author_sort Kang, Hun
collection PubMed
description We report a case of methimazole-induced acute hepatic failure, which occurred 17 weeks after initiation of the drug in a 43-year-old man with hyperthyroidism and hepatitis B surface antigenemia. Postmortem needle autopsy of the liver revealed an established micronodular cirrhosis secondary to hepatitis B with moderate septal/portal inflammation, marked cholestasis and scattered acidophilic bodies. The serum hepatitis B surface antigen (HBsAg) was positive, but reactivation of hepatitis B was unlikely in view of the absence of a serum hepatitis B e antigen (HBeAg) and hepatitis B virus deoxyribonucleic acid (HBV-DNA) and negative stain for HBsAg and hepatitis B core antigen (HBcAg) in the liver tissue.
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spelling pubmed-45350012015-10-02 A Case of Methimazole-Induced Acute Hepatic Failure in A Patient With Chronic Hepatitis B Carrier Kang, Hun Choi, Jong Do Jung, In Gu Kim, Dong Whan Kim, Tae Bin Shin, Ho Kyun Kim, Byung Tae Park, Choong Kee Yoo, Jae Young Korean J Intern Med Case Report We report a case of methimazole-induced acute hepatic failure, which occurred 17 weeks after initiation of the drug in a 43-year-old man with hyperthyroidism and hepatitis B surface antigenemia. Postmortem needle autopsy of the liver revealed an established micronodular cirrhosis secondary to hepatitis B with moderate septal/portal inflammation, marked cholestasis and scattered acidophilic bodies. The serum hepatitis B surface antigen (HBsAg) was positive, but reactivation of hepatitis B was unlikely in view of the absence of a serum hepatitis B e antigen (HBeAg) and hepatitis B virus deoxyribonucleic acid (HBV-DNA) and negative stain for HBsAg and hepatitis B core antigen (HBcAg) in the liver tissue. Korean Association of Internal Medicine 1990-01 /pmc/articles/PMC4535001/ /pubmed/2271514 http://dx.doi.org/10.3904/kjim.1990.5.1.69 Text en Copyright © 1990 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kang, Hun
Choi, Jong Do
Jung, In Gu
Kim, Dong Whan
Kim, Tae Bin
Shin, Ho Kyun
Kim, Byung Tae
Park, Choong Kee
Yoo, Jae Young
A Case of Methimazole-Induced Acute Hepatic Failure in A Patient With Chronic Hepatitis B Carrier
title A Case of Methimazole-Induced Acute Hepatic Failure in A Patient With Chronic Hepatitis B Carrier
title_full A Case of Methimazole-Induced Acute Hepatic Failure in A Patient With Chronic Hepatitis B Carrier
title_fullStr A Case of Methimazole-Induced Acute Hepatic Failure in A Patient With Chronic Hepatitis B Carrier
title_full_unstemmed A Case of Methimazole-Induced Acute Hepatic Failure in A Patient With Chronic Hepatitis B Carrier
title_short A Case of Methimazole-Induced Acute Hepatic Failure in A Patient With Chronic Hepatitis B Carrier
title_sort case of methimazole-induced acute hepatic failure in a patient with chronic hepatitis b carrier
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535001/
https://www.ncbi.nlm.nih.gov/pubmed/2271514
http://dx.doi.org/10.3904/kjim.1990.5.1.69
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