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Circulating HBsAg/IgG Complexes in idiopathic Chronic Glomerulonephritis

We measured HBsAg/IgG complexes (CX) quantitatively by ELISA from HBsAg positive serum of 35 liver disease patients, 15 patients with glomerular diseases (8 membranous glomerulonephritis (MGN) 7 membarnoproliferative glomerulonephritis (MPGN)), and 50 healthy carriers of HBsAg. HbsAg/IgG CX was dete...

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Detalles Bibliográficos
Autores principales: Hong, Sae Yong, Yang, Dong Ho, Park, Jong Myun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 1991
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535014/
https://www.ncbi.nlm.nih.gov/pubmed/1742252
http://dx.doi.org/10.3904/kjim.1991.6.1.21
Descripción
Sumario:We measured HBsAg/IgG complexes (CX) quantitatively by ELISA from HBsAg positive serum of 35 liver disease patients, 15 patients with glomerular diseases (8 membranous glomerulonephritis (MGN) 7 membarnoproliferative glomerulonephritis (MPGN)), and 50 healthy carriers of HBsAg. HbsAg/IgG CX was detected in 26 out of 35 liver disease patients (74.3%), 5 out of 50 healthy carriers (10%), and one of both 8 MGN patients (12.5%) and 7 MPGN patients (14.3%). HBsAg/IgG CX was big in size and wide spreaded in the liver disease groups but negligible in the healthy carrier group (41±2.6 ng/ml, n=5) and MGN (50 ng/ml n=1) and MPGN (42 ng/ml, n=1) group. In the liver disease group, no one suffered from glomerulopathy even with a wide spectrum of HBsAg/IgG CX. These results suggest that HBsAg/IgG CX in plasma is non causative of MGN and MPGN.