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Genome-wide copy number analysis of cerebrospinal fluid tumor cells and their corresponding archival primary tumors

A debilitating complication of breast cancer is the metastatic spread of tumor cells to the leptomeninges or cerebrospinal fluid (CSF). Patients diagnosed with this aggressive clinical syndrome, known as leptomeningeal carcinomatosis, have very poor prognosis. Despite improvements in detecting cereb...

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Autores principales: Magbanua, Mark Jesus M., Roy, Ritu, Sosa, Eduardo V., Hauranieh, Louai, Kablanian, Andrea, Eisenbud, Lauren E., Ryazantsev, Artem, Au, Alfred, Scott, Janet H., Melisko, Michelle, Park, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535622/
https://www.ncbi.nlm.nih.gov/pubmed/26484071
http://dx.doi.org/10.1016/j.gdata.2014.04.003
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author Magbanua, Mark Jesus M.
Roy, Ritu
Sosa, Eduardo V.
Hauranieh, Louai
Kablanian, Andrea
Eisenbud, Lauren E.
Ryazantsev, Artem
Au, Alfred
Scott, Janet H.
Melisko, Michelle
Park, John W.
author_facet Magbanua, Mark Jesus M.
Roy, Ritu
Sosa, Eduardo V.
Hauranieh, Louai
Kablanian, Andrea
Eisenbud, Lauren E.
Ryazantsev, Artem
Au, Alfred
Scott, Janet H.
Melisko, Michelle
Park, John W.
author_sort Magbanua, Mark Jesus M.
collection PubMed
description A debilitating complication of breast cancer is the metastatic spread of tumor cells to the leptomeninges or cerebrospinal fluid (CSF). Patients diagnosed with this aggressive clinical syndrome, known as leptomeningeal carcinomatosis, have very poor prognosis. Despite improvements in detecting cerebrospinal fluid tumor cells (CSFTCs), information regarding their molecular biology is extremely limited. In our recent work, we utilized a protocol previously used for circulating tumor cell isolation to purify tumor cells from the CSF. We then performed genomic characterization of CSFTCs as well as archival tumors from the same patient. Here, we describe the microarray data and quality controls associated with our study published in the Cancer Research journal in 2013 [1]. We also provide an R script containing code for quality control of microarray data and assessment of copy number calls. The microarray data has been deposited into Gene Expression Omnibus under accession # GSE46068.
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spelling pubmed-45356222015-10-19 Genome-wide copy number analysis of cerebrospinal fluid tumor cells and their corresponding archival primary tumors Magbanua, Mark Jesus M. Roy, Ritu Sosa, Eduardo V. Hauranieh, Louai Kablanian, Andrea Eisenbud, Lauren E. Ryazantsev, Artem Au, Alfred Scott, Janet H. Melisko, Michelle Park, John W. Genom Data Data in Brief A debilitating complication of breast cancer is the metastatic spread of tumor cells to the leptomeninges or cerebrospinal fluid (CSF). Patients diagnosed with this aggressive clinical syndrome, known as leptomeningeal carcinomatosis, have very poor prognosis. Despite improvements in detecting cerebrospinal fluid tumor cells (CSFTCs), information regarding their molecular biology is extremely limited. In our recent work, we utilized a protocol previously used for circulating tumor cell isolation to purify tumor cells from the CSF. We then performed genomic characterization of CSFTCs as well as archival tumors from the same patient. Here, we describe the microarray data and quality controls associated with our study published in the Cancer Research journal in 2013 [1]. We also provide an R script containing code for quality control of microarray data and assessment of copy number calls. The microarray data has been deposited into Gene Expression Omnibus under accession # GSE46068. Elsevier 2014-04-18 /pmc/articles/PMC4535622/ /pubmed/26484071 http://dx.doi.org/10.1016/j.gdata.2014.04.003 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Data in Brief
Magbanua, Mark Jesus M.
Roy, Ritu
Sosa, Eduardo V.
Hauranieh, Louai
Kablanian, Andrea
Eisenbud, Lauren E.
Ryazantsev, Artem
Au, Alfred
Scott, Janet H.
Melisko, Michelle
Park, John W.
Genome-wide copy number analysis of cerebrospinal fluid tumor cells and their corresponding archival primary tumors
title Genome-wide copy number analysis of cerebrospinal fluid tumor cells and their corresponding archival primary tumors
title_full Genome-wide copy number analysis of cerebrospinal fluid tumor cells and their corresponding archival primary tumors
title_fullStr Genome-wide copy number analysis of cerebrospinal fluid tumor cells and their corresponding archival primary tumors
title_full_unstemmed Genome-wide copy number analysis of cerebrospinal fluid tumor cells and their corresponding archival primary tumors
title_short Genome-wide copy number analysis of cerebrospinal fluid tumor cells and their corresponding archival primary tumors
title_sort genome-wide copy number analysis of cerebrospinal fluid tumor cells and their corresponding archival primary tumors
topic Data in Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535622/
https://www.ncbi.nlm.nih.gov/pubmed/26484071
http://dx.doi.org/10.1016/j.gdata.2014.04.003
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