Gene expression response to EWS–FLI1 in mouse embryonic cartilage

Ewing's sarcoma is a rare bone tumor that affects children and adolescents. We have recently succeeded to induce Ewing's sarcoma-like small round cell tumor in mice by expression of EWS–ETS fusion genes in murine embryonic osteochondrogenic progenitors. The Ewing's sarcoma precursors...

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Autores principales: Tanaka, Miwa, Aisaki, Ken-ichi, Kitajima, Satoshi, Igarashi, Katsuhide, Kanno, Jun, Nakamura, Takuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535656/
https://www.ncbi.nlm.nih.gov/pubmed/26484113
http://dx.doi.org/10.1016/j.gdata.2014.09.003
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author Tanaka, Miwa
Aisaki, Ken-ichi
Kitajima, Satoshi
Igarashi, Katsuhide
Kanno, Jun
Nakamura, Takuro
author_facet Tanaka, Miwa
Aisaki, Ken-ichi
Kitajima, Satoshi
Igarashi, Katsuhide
Kanno, Jun
Nakamura, Takuro
author_sort Tanaka, Miwa
collection PubMed
description Ewing's sarcoma is a rare bone tumor that affects children and adolescents. We have recently succeeded to induce Ewing's sarcoma-like small round cell tumor in mice by expression of EWS–ETS fusion genes in murine embryonic osteochondrogenic progenitors. The Ewing's sarcoma precursors are enriched in embryonic superficial zone (eSZ) cells of long bone. To get insights into the mechanisms of Ewing's sarcoma development, gene expression profiles between EWS–FLI1-sensitive eSZ cells and EWS–FLI1-resistant embryonic growth plate (eGP) cells were compared using DNA microarrays. Gene expression of eSZ and eGP cells (total, 30 samples) was evaluated with or without EWS–FLI1 expression 0, 8 or 48 h after gene transduction. Our data provide useful information for gene expression responses to fusion oncogenes in human sarcoma.
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spelling pubmed-45356562015-10-19 Gene expression response to EWS–FLI1 in mouse embryonic cartilage Tanaka, Miwa Aisaki, Ken-ichi Kitajima, Satoshi Igarashi, Katsuhide Kanno, Jun Nakamura, Takuro Genom Data Data in Brief Ewing's sarcoma is a rare bone tumor that affects children and adolescents. We have recently succeeded to induce Ewing's sarcoma-like small round cell tumor in mice by expression of EWS–ETS fusion genes in murine embryonic osteochondrogenic progenitors. The Ewing's sarcoma precursors are enriched in embryonic superficial zone (eSZ) cells of long bone. To get insights into the mechanisms of Ewing's sarcoma development, gene expression profiles between EWS–FLI1-sensitive eSZ cells and EWS–FLI1-resistant embryonic growth plate (eGP) cells were compared using DNA microarrays. Gene expression of eSZ and eGP cells (total, 30 samples) was evaluated with or without EWS–FLI1 expression 0, 8 or 48 h after gene transduction. Our data provide useful information for gene expression responses to fusion oncogenes in human sarcoma. Elsevier 2014-09-16 /pmc/articles/PMC4535656/ /pubmed/26484113 http://dx.doi.org/10.1016/j.gdata.2014.09.003 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Data in Brief
Tanaka, Miwa
Aisaki, Ken-ichi
Kitajima, Satoshi
Igarashi, Katsuhide
Kanno, Jun
Nakamura, Takuro
Gene expression response to EWS–FLI1 in mouse embryonic cartilage
title Gene expression response to EWS–FLI1 in mouse embryonic cartilage
title_full Gene expression response to EWS–FLI1 in mouse embryonic cartilage
title_fullStr Gene expression response to EWS–FLI1 in mouse embryonic cartilage
title_full_unstemmed Gene expression response to EWS–FLI1 in mouse embryonic cartilage
title_short Gene expression response to EWS–FLI1 in mouse embryonic cartilage
title_sort gene expression response to ews–fli1 in mouse embryonic cartilage
topic Data in Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535656/
https://www.ncbi.nlm.nih.gov/pubmed/26484113
http://dx.doi.org/10.1016/j.gdata.2014.09.003
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