Gene expression response to EWS–FLI1 in mouse embryonic cartilage
Ewing's sarcoma is a rare bone tumor that affects children and adolescents. We have recently succeeded to induce Ewing's sarcoma-like small round cell tumor in mice by expression of EWS–ETS fusion genes in murine embryonic osteochondrogenic progenitors. The Ewing's sarcoma precursors...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535656/ https://www.ncbi.nlm.nih.gov/pubmed/26484113 http://dx.doi.org/10.1016/j.gdata.2014.09.003 |
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author | Tanaka, Miwa Aisaki, Ken-ichi Kitajima, Satoshi Igarashi, Katsuhide Kanno, Jun Nakamura, Takuro |
author_facet | Tanaka, Miwa Aisaki, Ken-ichi Kitajima, Satoshi Igarashi, Katsuhide Kanno, Jun Nakamura, Takuro |
author_sort | Tanaka, Miwa |
collection | PubMed |
description | Ewing's sarcoma is a rare bone tumor that affects children and adolescents. We have recently succeeded to induce Ewing's sarcoma-like small round cell tumor in mice by expression of EWS–ETS fusion genes in murine embryonic osteochondrogenic progenitors. The Ewing's sarcoma precursors are enriched in embryonic superficial zone (eSZ) cells of long bone. To get insights into the mechanisms of Ewing's sarcoma development, gene expression profiles between EWS–FLI1-sensitive eSZ cells and EWS–FLI1-resistant embryonic growth plate (eGP) cells were compared using DNA microarrays. Gene expression of eSZ and eGP cells (total, 30 samples) was evaluated with or without EWS–FLI1 expression 0, 8 or 48 h after gene transduction. Our data provide useful information for gene expression responses to fusion oncogenes in human sarcoma. |
format | Online Article Text |
id | pubmed-4535656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-45356562015-10-19 Gene expression response to EWS–FLI1 in mouse embryonic cartilage Tanaka, Miwa Aisaki, Ken-ichi Kitajima, Satoshi Igarashi, Katsuhide Kanno, Jun Nakamura, Takuro Genom Data Data in Brief Ewing's sarcoma is a rare bone tumor that affects children and adolescents. We have recently succeeded to induce Ewing's sarcoma-like small round cell tumor in mice by expression of EWS–ETS fusion genes in murine embryonic osteochondrogenic progenitors. The Ewing's sarcoma precursors are enriched in embryonic superficial zone (eSZ) cells of long bone. To get insights into the mechanisms of Ewing's sarcoma development, gene expression profiles between EWS–FLI1-sensitive eSZ cells and EWS–FLI1-resistant embryonic growth plate (eGP) cells were compared using DNA microarrays. Gene expression of eSZ and eGP cells (total, 30 samples) was evaluated with or without EWS–FLI1 expression 0, 8 or 48 h after gene transduction. Our data provide useful information for gene expression responses to fusion oncogenes in human sarcoma. Elsevier 2014-09-16 /pmc/articles/PMC4535656/ /pubmed/26484113 http://dx.doi.org/10.1016/j.gdata.2014.09.003 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Data in Brief Tanaka, Miwa Aisaki, Ken-ichi Kitajima, Satoshi Igarashi, Katsuhide Kanno, Jun Nakamura, Takuro Gene expression response to EWS–FLI1 in mouse embryonic cartilage |
title | Gene expression response to EWS–FLI1 in mouse embryonic cartilage |
title_full | Gene expression response to EWS–FLI1 in mouse embryonic cartilage |
title_fullStr | Gene expression response to EWS–FLI1 in mouse embryonic cartilage |
title_full_unstemmed | Gene expression response to EWS–FLI1 in mouse embryonic cartilage |
title_short | Gene expression response to EWS–FLI1 in mouse embryonic cartilage |
title_sort | gene expression response to ews–fli1 in mouse embryonic cartilage |
topic | Data in Brief |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535656/ https://www.ncbi.nlm.nih.gov/pubmed/26484113 http://dx.doi.org/10.1016/j.gdata.2014.09.003 |
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