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Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase**

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Elaiophylin is an unusual C(2)-symmetric antibiotic macrodiolide produced on a bacterial modular polyketide synthase assembly line. To probe the mechanism and selectivity of diolide formation, we sought to reconstitute ring formation in vitro by using a non-natural substrate. Incubation of recombina...

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Detalles Bibliográficos
Autores principales:	Zhou, Yongjun, Prediger, Patrícia, Dias, Luiz Carlos, Murphy, Annabel C, Leadlay, Peter F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2015
Materias:	Zuschriften
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535664/ https://www.ncbi.nlm.nih.gov/pubmed/26300568 http://dx.doi.org/10.1002/ange.201500401

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