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Genome-wide gene expression profiling of acute metal exposures in male zebrafish
To capture global responses to metal poisoning and mechanistic insights into metal toxicity, gene expression changes were evaluated in whole adult male zebrafish following acute 24 h high dose exposure to three metals with known human health risks. Male adult zebrafish were exposed to nickel chlorid...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535742/ https://www.ncbi.nlm.nih.gov/pubmed/26484131 http://dx.doi.org/10.1016/j.gdata.2014.10.013 |
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author | Baer, Christine E. Ippolito, Danielle L. Hussainzada, Naissan Lewis, John A. Jackson, David A. Stallings, Jonathan D. |
author_facet | Baer, Christine E. Ippolito, Danielle L. Hussainzada, Naissan Lewis, John A. Jackson, David A. Stallings, Jonathan D. |
author_sort | Baer, Christine E. |
collection | PubMed |
description | To capture global responses to metal poisoning and mechanistic insights into metal toxicity, gene expression changes were evaluated in whole adult male zebrafish following acute 24 h high dose exposure to three metals with known human health risks. Male adult zebrafish were exposed to nickel chloride, cobalt chloride or sodium dichromate at concentrations corresponding to their respective 96 h LC(20), LC(40) and LC(60) (i.e. 96 h concentrations at which 20%, 40% and 60% lethality is expected, respectively). Histopathology was performed on a subset of metal-exposed zebrafish to phenotypically anchor transcriptional changes associated with each metal exposure. Here we describe in detail the contents and quality controls for the gene expression and other data associated with the study published by Hussainzada and colleagues in BMC Pharmacology and Toxicology (Hussainzada et al., 2014) with the data uploaded to Gene Expression Omnibus (accession number GSE50648). |
format | Online Article Text |
id | pubmed-4535742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-45357422015-10-19 Genome-wide gene expression profiling of acute metal exposures in male zebrafish Baer, Christine E. Ippolito, Danielle L. Hussainzada, Naissan Lewis, John A. Jackson, David A. Stallings, Jonathan D. Genom Data Data in Brief To capture global responses to metal poisoning and mechanistic insights into metal toxicity, gene expression changes were evaluated in whole adult male zebrafish following acute 24 h high dose exposure to three metals with known human health risks. Male adult zebrafish were exposed to nickel chloride, cobalt chloride or sodium dichromate at concentrations corresponding to their respective 96 h LC(20), LC(40) and LC(60) (i.e. 96 h concentrations at which 20%, 40% and 60% lethality is expected, respectively). Histopathology was performed on a subset of metal-exposed zebrafish to phenotypically anchor transcriptional changes associated with each metal exposure. Here we describe in detail the contents and quality controls for the gene expression and other data associated with the study published by Hussainzada and colleagues in BMC Pharmacology and Toxicology (Hussainzada et al., 2014) with the data uploaded to Gene Expression Omnibus (accession number GSE50648). Elsevier 2014-10-23 /pmc/articles/PMC4535742/ /pubmed/26484131 http://dx.doi.org/10.1016/j.gdata.2014.10.013 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Data in Brief Baer, Christine E. Ippolito, Danielle L. Hussainzada, Naissan Lewis, John A. Jackson, David A. Stallings, Jonathan D. Genome-wide gene expression profiling of acute metal exposures in male zebrafish |
title | Genome-wide gene expression profiling of acute metal exposures in male zebrafish |
title_full | Genome-wide gene expression profiling of acute metal exposures in male zebrafish |
title_fullStr | Genome-wide gene expression profiling of acute metal exposures in male zebrafish |
title_full_unstemmed | Genome-wide gene expression profiling of acute metal exposures in male zebrafish |
title_short | Genome-wide gene expression profiling of acute metal exposures in male zebrafish |
title_sort | genome-wide gene expression profiling of acute metal exposures in male zebrafish |
topic | Data in Brief |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535742/ https://www.ncbi.nlm.nih.gov/pubmed/26484131 http://dx.doi.org/10.1016/j.gdata.2014.10.013 |
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