Cargando…
In Silico Adoption of an Orphan Nuclear Receptor NR4A1
A 4.1μs molecular dynamics simulation of the NR4A1 (hNur77) apo-protein has been undertaken and a previously undetected druggable pocket has become apparent that is located remotely from the ‘traditional’ nuclear receptor ligand-binding site. A NR4A1/bis-indole ligand complex at this novel site has...
Autores principales: | Lanig, Harald, Reisen, Felix, Whitley, David, Schneider, Gisbert, Banting, Lee, Clark, Timothy |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535767/ https://www.ncbi.nlm.nih.gov/pubmed/26270486 http://dx.doi.org/10.1371/journal.pone.0135246 |
Ejemplares similares
-
Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes
por: Zhang, Chenyang, et al.
Publicado: (2020) -
Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology
por: Odagiu, Livia, et al.
Publicado: (2021) -
Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1)
por: Lee, Miok, et al.
Publicado: (2023) -
Piperlongumine is a ligand for the orphan nuclear receptor 4A1 (NR4A1)
por: Zhang, Lei, et al.
Publicado: (2023) -
Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin
por: McCoy, Joseph M, et al.
Publicado: (2015)