Destabilizing DNA during Rejoining Enhances Fidelity of Repair

A new study shows that during repair of DNA, the effect of a single-strand annealing protein is to destabilize DNA duplex formation so that annealing only occurs between perfectly matched strands; the protein then clamps the strands together for repair. Read the Research Article.

Detalles Bibliográficos
Autor principal: Robinson, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Synopsis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535887/
https://www.ncbi.nlm.nih.gov/pubmed/26271078
http://dx.doi.org/10.1371/journal.pbio.1002214
Descripción
Sumario:A new study shows that during repair of DNA, the effect of a single-strand annealing protein is to destabilize DNA duplex formation so that annealing only occurs between perfectly matched strands; the protein then clamps the strands together for repair. Read the Research Article.

Ejemplares similares