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Destabilizing DNA during Rejoining Enhances Fidelity of Repair

A new study shows that during repair of DNA, the effect of a single-strand annealing protein is to destabilize DNA duplex formation so that annealing only occurs between perfectly matched strands; the protein then clamps the strands together for repair. Read the Research Article.

Detalles Bibliográficos
Autor principal: Robinson, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535887/
https://www.ncbi.nlm.nih.gov/pubmed/26271078
http://dx.doi.org/10.1371/journal.pbio.1002214
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author Robinson, Richard
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description A new study shows that during repair of DNA, the effect of a single-strand annealing protein is to destabilize DNA duplex formation so that annealing only occurs between perfectly matched strands; the protein then clamps the strands together for repair. Read the Research Article.
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spelling pubmed-45358872015-08-20 Destabilizing DNA during Rejoining Enhances Fidelity of Repair Robinson, Richard PLoS Biol Synopsis A new study shows that during repair of DNA, the effect of a single-strand annealing protein is to destabilize DNA duplex formation so that annealing only occurs between perfectly matched strands; the protein then clamps the strands together for repair. Read the Research Article. Public Library of Science 2015-08-13 /pmc/articles/PMC4535887/ /pubmed/26271078 http://dx.doi.org/10.1371/journal.pbio.1002214 Text en © 2015 Richard Robinson http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Synopsis
Robinson, Richard
Destabilizing DNA during Rejoining Enhances Fidelity of Repair
title Destabilizing DNA during Rejoining Enhances Fidelity of Repair
title_full Destabilizing DNA during Rejoining Enhances Fidelity of Repair
title_fullStr Destabilizing DNA during Rejoining Enhances Fidelity of Repair
title_full_unstemmed Destabilizing DNA during Rejoining Enhances Fidelity of Repair
title_short Destabilizing DNA during Rejoining Enhances Fidelity of Repair
title_sort destabilizing dna during rejoining enhances fidelity of repair
topic Synopsis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535887/
https://www.ncbi.nlm.nih.gov/pubmed/26271078
http://dx.doi.org/10.1371/journal.pbio.1002214
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