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Destabilizing DNA during Rejoining Enhances Fidelity of Repair
A new study shows that during repair of DNA, the effect of a single-strand annealing protein is to destabilize DNA duplex formation so that annealing only occurs between perfectly matched strands; the protein then clamps the strands together for repair. Read the Research Article.
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535887/ https://www.ncbi.nlm.nih.gov/pubmed/26271078 http://dx.doi.org/10.1371/journal.pbio.1002214 |
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author | Robinson, Richard |
author_facet | Robinson, Richard |
author_sort | Robinson, Richard |
collection | PubMed |
description | A new study shows that during repair of DNA, the effect of a single-strand annealing protein is to destabilize DNA duplex formation so that annealing only occurs between perfectly matched strands; the protein then clamps the strands together for repair. Read the Research Article. |
format | Online Article Text |
id | pubmed-4535887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45358872015-08-20 Destabilizing DNA during Rejoining Enhances Fidelity of Repair Robinson, Richard PLoS Biol Synopsis A new study shows that during repair of DNA, the effect of a single-strand annealing protein is to destabilize DNA duplex formation so that annealing only occurs between perfectly matched strands; the protein then clamps the strands together for repair. Read the Research Article. Public Library of Science 2015-08-13 /pmc/articles/PMC4535887/ /pubmed/26271078 http://dx.doi.org/10.1371/journal.pbio.1002214 Text en © 2015 Richard Robinson http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Synopsis Robinson, Richard Destabilizing DNA during Rejoining Enhances Fidelity of Repair |
title | Destabilizing DNA during Rejoining Enhances Fidelity of Repair |
title_full | Destabilizing DNA during Rejoining Enhances Fidelity of Repair |
title_fullStr | Destabilizing DNA during Rejoining Enhances Fidelity of Repair |
title_full_unstemmed | Destabilizing DNA during Rejoining Enhances Fidelity of Repair |
title_short | Destabilizing DNA during Rejoining Enhances Fidelity of Repair |
title_sort | destabilizing dna during rejoining enhances fidelity of repair |
topic | Synopsis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535887/ https://www.ncbi.nlm.nih.gov/pubmed/26271078 http://dx.doi.org/10.1371/journal.pbio.1002214 |
work_keys_str_mv | AT robinsonrichard destabilizingdnaduringrejoiningenhancesfidelityofrepair |