A microarray analysis of two distinct lymphatic endothelial cell populations

We have recently identified lymphatic endothelial cells (LECs) to form two morphologically different populations, exhibiting significantly different surface protein expression levels of podoplanin, a major surface marker for this cell type. In vitro shockwave treatment (IVSWT) of LECs resulted in en...

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Detalles Bibliográficos
Autores principales: Schweighofer, Bernhard, Rohringer, Sabrina, Pröll, Johannes, Holnthoner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data in Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535941/
https://www.ncbi.nlm.nih.gov/pubmed/26484194
http://dx.doi.org/10.1016/j.gdata.2015.04.005
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author Schweighofer, Bernhard
Rohringer, Sabrina
Pröll, Johannes
Holnthoner, Wolfgang
author_facet Schweighofer, Bernhard
Rohringer, Sabrina
Pröll, Johannes
Holnthoner, Wolfgang
author_sort Schweighofer, Bernhard
collection PubMed
description We have recently identified lymphatic endothelial cells (LECs) to form two morphologically different populations, exhibiting significantly different surface protein expression levels of podoplanin, a major surface marker for this cell type. In vitro shockwave treatment (IVSWT) of LECs resulted in enrichment of the podoplanin(high) cell population and was accompanied by markedly increased cell proliferation, as well as 2D and 3D migration. Gene expression profiles of these distinct populations were established using Affymetrix microarray analyses. Here we provide additional details about our dataset (NCBI GEO accession number GSE62510) and describe how we analyzed the data to identify differently expressed genes in these two LEC populations.
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spelling pubmed-45359412015-10-19 A microarray analysis of two distinct lymphatic endothelial cell populations Schweighofer, Bernhard Rohringer, Sabrina Pröll, Johannes Holnthoner, Wolfgang Genom Data Data in Brief We have recently identified lymphatic endothelial cells (LECs) to form two morphologically different populations, exhibiting significantly different surface protein expression levels of podoplanin, a major surface marker for this cell type. In vitro shockwave treatment (IVSWT) of LECs resulted in enrichment of the podoplanin(high) cell population and was accompanied by markedly increased cell proliferation, as well as 2D and 3D migration. Gene expression profiles of these distinct populations were established using Affymetrix microarray analyses. Here we provide additional details about our dataset (NCBI GEO accession number GSE62510) and describe how we analyzed the data to identify differently expressed genes in these two LEC populations. Elsevier 2015-04-11 /pmc/articles/PMC4535941/ /pubmed/26484194 http://dx.doi.org/10.1016/j.gdata.2015.04.005 Text en © 2015 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Data in Brief
Schweighofer, Bernhard
Rohringer, Sabrina
Pröll, Johannes
Holnthoner, Wolfgang
A microarray analysis of two distinct lymphatic endothelial cell populations
title A microarray analysis of two distinct lymphatic endothelial cell populations
title_full A microarray analysis of two distinct lymphatic endothelial cell populations
title_fullStr A microarray analysis of two distinct lymphatic endothelial cell populations
title_full_unstemmed A microarray analysis of two distinct lymphatic endothelial cell populations
title_short A microarray analysis of two distinct lymphatic endothelial cell populations
title_sort microarray analysis of two distinct lymphatic endothelial cell populations
topic Data in Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535941/
https://www.ncbi.nlm.nih.gov/pubmed/26484194
http://dx.doi.org/10.1016/j.gdata.2015.04.005
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