Cargando…
Human Neural Cells Transiently Express Reelin during Olfactory Placode Development
Reelin, an extracellular glycoprotein is essential for migration and correct positioning of neurons during development. Since the olfactory system is known as a source of various migrating neuronal cells, we studied Reelin expression in the two chemosensory olfactory systems, main and accessory, dur...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535952/ https://www.ncbi.nlm.nih.gov/pubmed/26270645 http://dx.doi.org/10.1371/journal.pone.0135710 |
_version_ | 1782385676362186752 |
---|---|
author | Antal, M. Cristina Samama, Brigitte Ghandour, M. Said Boehm, Nelly |
author_facet | Antal, M. Cristina Samama, Brigitte Ghandour, M. Said Boehm, Nelly |
author_sort | Antal, M. Cristina |
collection | PubMed |
description | Reelin, an extracellular glycoprotein is essential for migration and correct positioning of neurons during development. Since the olfactory system is known as a source of various migrating neuronal cells, we studied Reelin expression in the two chemosensory olfactory systems, main and accessory, during early developmental stages of human foetuses/embryos from Carnegie Stage (CS) 15 to gestational week (GW) 14. From CS 15 to CS 18, but not at later stages, a transient expression of Reelin was detected first in the presumptive olfactory and then in the presumptive vomeronasal epithelium. During the same period, Reelin-positive cells detach from the olfactory/vomeronasal epithelium and migrate through the mesenchyme beneath the telencephalon. Dab 1, an adaptor protein of the Reelin pathway, was simultaneously expressed in the migratory mass from CS16 to CS17 and, at later stages, in the presumptive olfactory ensheathing cells. Possible involvements of Reelin and Dab 1 in the peripheral migrating stream are discussed. |
format | Online Article Text |
id | pubmed-4535952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45359522015-08-20 Human Neural Cells Transiently Express Reelin during Olfactory Placode Development Antal, M. Cristina Samama, Brigitte Ghandour, M. Said Boehm, Nelly PLoS One Research Article Reelin, an extracellular glycoprotein is essential for migration and correct positioning of neurons during development. Since the olfactory system is known as a source of various migrating neuronal cells, we studied Reelin expression in the two chemosensory olfactory systems, main and accessory, during early developmental stages of human foetuses/embryos from Carnegie Stage (CS) 15 to gestational week (GW) 14. From CS 15 to CS 18, but not at later stages, a transient expression of Reelin was detected first in the presumptive olfactory and then in the presumptive vomeronasal epithelium. During the same period, Reelin-positive cells detach from the olfactory/vomeronasal epithelium and migrate through the mesenchyme beneath the telencephalon. Dab 1, an adaptor protein of the Reelin pathway, was simultaneously expressed in the migratory mass from CS16 to CS17 and, at later stages, in the presumptive olfactory ensheathing cells. Possible involvements of Reelin and Dab 1 in the peripheral migrating stream are discussed. Public Library of Science 2015-08-13 /pmc/articles/PMC4535952/ /pubmed/26270645 http://dx.doi.org/10.1371/journal.pone.0135710 Text en © 2015 Antal et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Antal, M. Cristina Samama, Brigitte Ghandour, M. Said Boehm, Nelly Human Neural Cells Transiently Express Reelin during Olfactory Placode Development |
title | Human Neural Cells Transiently Express Reelin during Olfactory Placode Development |
title_full | Human Neural Cells Transiently Express Reelin during Olfactory Placode Development |
title_fullStr | Human Neural Cells Transiently Express Reelin during Olfactory Placode Development |
title_full_unstemmed | Human Neural Cells Transiently Express Reelin during Olfactory Placode Development |
title_short | Human Neural Cells Transiently Express Reelin during Olfactory Placode Development |
title_sort | human neural cells transiently express reelin during olfactory placode development |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535952/ https://www.ncbi.nlm.nih.gov/pubmed/26270645 http://dx.doi.org/10.1371/journal.pone.0135710 |
work_keys_str_mv | AT antalmcristina humanneuralcellstransientlyexpressreelinduringolfactoryplacodedevelopment AT samamabrigitte humanneuralcellstransientlyexpressreelinduringolfactoryplacodedevelopment AT ghandourmsaid humanneuralcellstransientlyexpressreelinduringolfactoryplacodedevelopment AT boehmnelly humanneuralcellstransientlyexpressreelinduringolfactoryplacodedevelopment |