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Human Neural Cells Transiently Express Reelin during Olfactory Placode Development

Reelin, an extracellular glycoprotein is essential for migration and correct positioning of neurons during development. Since the olfactory system is known as a source of various migrating neuronal cells, we studied Reelin expression in the two chemosensory olfactory systems, main and accessory, dur...

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Detalles Bibliográficos
Autores principales: Antal, M. Cristina, Samama, Brigitte, Ghandour, M. Said, Boehm, Nelly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535952/
https://www.ncbi.nlm.nih.gov/pubmed/26270645
http://dx.doi.org/10.1371/journal.pone.0135710
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author Antal, M. Cristina
Samama, Brigitte
Ghandour, M. Said
Boehm, Nelly
author_facet Antal, M. Cristina
Samama, Brigitte
Ghandour, M. Said
Boehm, Nelly
author_sort Antal, M. Cristina
collection PubMed
description Reelin, an extracellular glycoprotein is essential for migration and correct positioning of neurons during development. Since the olfactory system is known as a source of various migrating neuronal cells, we studied Reelin expression in the two chemosensory olfactory systems, main and accessory, during early developmental stages of human foetuses/embryos from Carnegie Stage (CS) 15 to gestational week (GW) 14. From CS 15 to CS 18, but not at later stages, a transient expression of Reelin was detected first in the presumptive olfactory and then in the presumptive vomeronasal epithelium. During the same period, Reelin-positive cells detach from the olfactory/vomeronasal epithelium and migrate through the mesenchyme beneath the telencephalon. Dab 1, an adaptor protein of the Reelin pathway, was simultaneously expressed in the migratory mass from CS16 to CS17 and, at later stages, in the presumptive olfactory ensheathing cells. Possible involvements of Reelin and Dab 1 in the peripheral migrating stream are discussed.
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spelling pubmed-45359522015-08-20 Human Neural Cells Transiently Express Reelin during Olfactory Placode Development Antal, M. Cristina Samama, Brigitte Ghandour, M. Said Boehm, Nelly PLoS One Research Article Reelin, an extracellular glycoprotein is essential for migration and correct positioning of neurons during development. Since the olfactory system is known as a source of various migrating neuronal cells, we studied Reelin expression in the two chemosensory olfactory systems, main and accessory, during early developmental stages of human foetuses/embryos from Carnegie Stage (CS) 15 to gestational week (GW) 14. From CS 15 to CS 18, but not at later stages, a transient expression of Reelin was detected first in the presumptive olfactory and then in the presumptive vomeronasal epithelium. During the same period, Reelin-positive cells detach from the olfactory/vomeronasal epithelium and migrate through the mesenchyme beneath the telencephalon. Dab 1, an adaptor protein of the Reelin pathway, was simultaneously expressed in the migratory mass from CS16 to CS17 and, at later stages, in the presumptive olfactory ensheathing cells. Possible involvements of Reelin and Dab 1 in the peripheral migrating stream are discussed. Public Library of Science 2015-08-13 /pmc/articles/PMC4535952/ /pubmed/26270645 http://dx.doi.org/10.1371/journal.pone.0135710 Text en © 2015 Antal et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Antal, M. Cristina
Samama, Brigitte
Ghandour, M. Said
Boehm, Nelly
Human Neural Cells Transiently Express Reelin during Olfactory Placode Development
title Human Neural Cells Transiently Express Reelin during Olfactory Placode Development
title_full Human Neural Cells Transiently Express Reelin during Olfactory Placode Development
title_fullStr Human Neural Cells Transiently Express Reelin during Olfactory Placode Development
title_full_unstemmed Human Neural Cells Transiently Express Reelin during Olfactory Placode Development
title_short Human Neural Cells Transiently Express Reelin during Olfactory Placode Development
title_sort human neural cells transiently express reelin during olfactory placode development
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535952/
https://www.ncbi.nlm.nih.gov/pubmed/26270645
http://dx.doi.org/10.1371/journal.pone.0135710
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