Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity

Paternal high fat diet (HFD) consumption triggers unique gene signatures, consistent with premature aging and chronic degenerative disorders, in both white adipose tissue (RpWAT) and pancreatic islets of daughters. In addition to published data in Nature, 2010, 467, 963–966 (GSE: 19877, islet) and F...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Ruby C.Y., Ng, Sheau-Fang, Morris, Margaret J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Data in Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536069/
https://www.ncbi.nlm.nih.gov/pubmed/26484128
http://dx.doi.org/10.1016/j.gdata.2014.09.013
_version_ 1782385697004453888
author Lin, Ruby C.Y.
Ng, Sheau-Fang
Morris, Margaret J.
author_facet Lin, Ruby C.Y.
Ng, Sheau-Fang
Morris, Margaret J.
author_sort Lin, Ruby C.Y.
collection PubMed
description Paternal high fat diet (HFD) consumption triggers unique gene signatures, consistent with premature aging and chronic degenerative disorders, in both white adipose tissue (RpWAT) and pancreatic islets of daughters. In addition to published data in Nature, 2010, 467, 963–966 (GSE: 19877, islet) and FASEB J 2014, 28, 1830–1841 (GSE: 33551, RpWAT), we describe here additional details on systems-based approaches and analysis to develop our observations. Our data provides a resource for exploring the complex molecular mechanisms that underlie intergenerational transmission of obesity.
format Online
Article
Text
id pubmed-4536069
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-45360692015-10-19 Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity Lin, Ruby C.Y. Ng, Sheau-Fang Morris, Margaret J. Genom Data Data in Brief Paternal high fat diet (HFD) consumption triggers unique gene signatures, consistent with premature aging and chronic degenerative disorders, in both white adipose tissue (RpWAT) and pancreatic islets of daughters. In addition to published data in Nature, 2010, 467, 963–966 (GSE: 19877, islet) and FASEB J 2014, 28, 1830–1841 (GSE: 33551, RpWAT), we describe here additional details on systems-based approaches and analysis to develop our observations. Our data provides a resource for exploring the complex molecular mechanisms that underlie intergenerational transmission of obesity. Elsevier 2014-10-16 /pmc/articles/PMC4536069/ /pubmed/26484128 http://dx.doi.org/10.1016/j.gdata.2014.09.013 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Data in Brief
Lin, Ruby C.Y.
Ng, Sheau-Fang
Morris, Margaret J.
Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity
title Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity
title_full Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity
title_fullStr Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity
title_full_unstemmed Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity
title_short Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity
title_sort gene expression in rat models for inter-generational transmission of islet dysfunction and obesity
topic Data in Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536069/
https://www.ncbi.nlm.nih.gov/pubmed/26484128
http://dx.doi.org/10.1016/j.gdata.2014.09.013
work_keys_str_mv AT linrubycy geneexpressioninratmodelsforintergenerationaltransmissionofisletdysfunctionandobesity
AT ngsheaufang geneexpressioninratmodelsforintergenerationaltransmissionofisletdysfunctionandobesity
AT morrismargaretj geneexpressioninratmodelsforintergenerationaltransmissionofisletdysfunctionandobesity

Ejemplares similares