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Automation, consolidation, and integration in autoimmune diagnostics
Over the past two decades, we have witnessed an extraordinary change in autoimmune diagnostics, characterized by the progressive evolution of analytical technologies, the availability of new tests, and the explosive growth of molecular biology and proteomics. Aside from these huge improvements, orga...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536237/ https://www.ncbi.nlm.nih.gov/pubmed/26138781 http://dx.doi.org/10.1007/s13317-015-0067-5 |
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author | Tozzoli, Renato D’Aurizio, Federica Villalta, Danilo Bizzaro, Nicola |
author_facet | Tozzoli, Renato D’Aurizio, Federica Villalta, Danilo Bizzaro, Nicola |
author_sort | Tozzoli, Renato |
collection | PubMed |
description | Over the past two decades, we have witnessed an extraordinary change in autoimmune diagnostics, characterized by the progressive evolution of analytical technologies, the availability of new tests, and the explosive growth of molecular biology and proteomics. Aside from these huge improvements, organizational changes have also occurred which brought about a more modern vision of the autoimmune laboratory. The introduction of automation (for harmonization of testing, reduction of human error, reduction of handling steps, increase of productivity, decrease of turnaround time, improvement of safety), consolidation (combining different analytical technologies or strategies on one instrument or on one group of connected instruments) and integration (linking analytical instruments or group of instruments with pre- and post-analytical devices) opened a new era in immunodiagnostics. In this article, we review the most important changes that have occurred in autoimmune diagnostics and present some models related to the introduction of automation in the autoimmunology laboratory, such as automated indirect immunofluorescence and changes in the two-step strategy for detection of autoantibodies; automated monoplex immunoassays and reduction of turnaround time; and automated multiplex immunoassays for autoantibody profiling. |
format | Online Article Text |
id | pubmed-4536237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-45362372015-08-15 Automation, consolidation, and integration in autoimmune diagnostics Tozzoli, Renato D’Aurizio, Federica Villalta, Danilo Bizzaro, Nicola Auto Immun Highlights Review Article Over the past two decades, we have witnessed an extraordinary change in autoimmune diagnostics, characterized by the progressive evolution of analytical technologies, the availability of new tests, and the explosive growth of molecular biology and proteomics. Aside from these huge improvements, organizational changes have also occurred which brought about a more modern vision of the autoimmune laboratory. The introduction of automation (for harmonization of testing, reduction of human error, reduction of handling steps, increase of productivity, decrease of turnaround time, improvement of safety), consolidation (combining different analytical technologies or strategies on one instrument or on one group of connected instruments) and integration (linking analytical instruments or group of instruments with pre- and post-analytical devices) opened a new era in immunodiagnostics. In this article, we review the most important changes that have occurred in autoimmune diagnostics and present some models related to the introduction of automation in the autoimmunology laboratory, such as automated indirect immunofluorescence and changes in the two-step strategy for detection of autoantibodies; automated monoplex immunoassays and reduction of turnaround time; and automated multiplex immunoassays for autoantibody profiling. Springer International Publishing 2015-07-03 /pmc/articles/PMC4536237/ /pubmed/26138781 http://dx.doi.org/10.1007/s13317-015-0067-5 Text en © The Author(s) 2015 |
spellingShingle | Review Article Tozzoli, Renato D’Aurizio, Federica Villalta, Danilo Bizzaro, Nicola Automation, consolidation, and integration in autoimmune diagnostics |
title | Automation, consolidation, and integration in autoimmune diagnostics |
title_full | Automation, consolidation, and integration in autoimmune diagnostics |
title_fullStr | Automation, consolidation, and integration in autoimmune diagnostics |
title_full_unstemmed | Automation, consolidation, and integration in autoimmune diagnostics |
title_short | Automation, consolidation, and integration in autoimmune diagnostics |
title_sort | automation, consolidation, and integration in autoimmune diagnostics |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536237/ https://www.ncbi.nlm.nih.gov/pubmed/26138781 http://dx.doi.org/10.1007/s13317-015-0067-5 |
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