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Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy

INTRODUCTION: Myoclonus may be a rare complication of stem cell transplant but has limited discussion in the scientific literature. CASE: We present a case of an acute myeloid leukemia survivor who developed refractory myoclonic epilepsy four years after graft versus host disease (GVHD) developed si...

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Autores principales: Robuccio, Anna, Ssentongo, Paddy, Sather, Michael D., Claxton, David F., Gilliam, Frank G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536288/
https://www.ncbi.nlm.nih.gov/pubmed/26288756
http://dx.doi.org/10.1016/j.ebcr.2015.06.005
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author Robuccio, Anna
Ssentongo, Paddy
Sather, Michael D.
Claxton, David F.
Gilliam, Frank G.
author_facet Robuccio, Anna
Ssentongo, Paddy
Sather, Michael D.
Claxton, David F.
Gilliam, Frank G.
author_sort Robuccio, Anna
collection PubMed
description INTRODUCTION: Myoclonus may be a rare complication of stem cell transplant but has limited discussion in the scientific literature. CASE: We present a case of an acute myeloid leukemia survivor who developed refractory myoclonic epilepsy four years after graft versus host disease (GVHD) developed six days following matched unrelated allogeneic hematopoietic stem cell transplant. DISCUSSION: Graft versus host disease occurs in 30–50% of allogenic hematopoietic stem cell transplant patients and may cause pharmacoresistant myoclonic epilepsy; however, the mechanisms by which GVHD leads to recurrent myoclonic seizures are not well understood (Lee, 2005) [1]. The paucity of clinical reports of such manifestation makes it difficult to diagnose and effectively manage these patients.
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spelling pubmed-45362882015-08-18 Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy Robuccio, Anna Ssentongo, Paddy Sather, Michael D. Claxton, David F. Gilliam, Frank G. Epilepsy Behav Case Rep Case Report INTRODUCTION: Myoclonus may be a rare complication of stem cell transplant but has limited discussion in the scientific literature. CASE: We present a case of an acute myeloid leukemia survivor who developed refractory myoclonic epilepsy four years after graft versus host disease (GVHD) developed six days following matched unrelated allogeneic hematopoietic stem cell transplant. DISCUSSION: Graft versus host disease occurs in 30–50% of allogenic hematopoietic stem cell transplant patients and may cause pharmacoresistant myoclonic epilepsy; however, the mechanisms by which GVHD leads to recurrent myoclonic seizures are not well understood (Lee, 2005) [1]. The paucity of clinical reports of such manifestation makes it difficult to diagnose and effectively manage these patients. Elsevier 2015-08-08 /pmc/articles/PMC4536288/ /pubmed/26288756 http://dx.doi.org/10.1016/j.ebcr.2015.06.005 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Robuccio, Anna
Ssentongo, Paddy
Sather, Michael D.
Claxton, David F.
Gilliam, Frank G.
Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy
title Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy
title_full Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy
title_fullStr Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy
title_full_unstemmed Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy
title_short Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy
title_sort intractable myoclonic seizures in an allogeneic stem cell transplant recipient: a rare case of myoclonic epilepsy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536288/
https://www.ncbi.nlm.nih.gov/pubmed/26288756
http://dx.doi.org/10.1016/j.ebcr.2015.06.005
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