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Assessment of metal-assisted nucleophile activation in the hepatitis delta virus ribozyme from molecular simulation and 3D-RISM

The hepatitis delta virus ribozyme is an efficient catalyst of RNA 2′-O-transphosphorylation and has emerged as a key experimental system for identifying and characterizing fundamental features of RNA catalysis. Recent structural and biochemical data have led to a proposed mechanistic model whereby...

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Detalles Bibliográficos
Autores principales:	Radak, Brian K., Lee, Tai-Sung, Harris, Michael E., York, Darrin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536318/ https://www.ncbi.nlm.nih.gov/pubmed/26170378 http://dx.doi.org/10.1261/rna.051466.115

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