Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes

The biomechanics stress and chronic inflammation in obesity are causally linked to osteoarthritis. However, the metabolic factors mediating obesity-related osteoarthritis are still obscure. Here we scanned and identified at least two elevated metabolites (stearic acid and lactate) from the plasma of...

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Detalles Bibliográficos
Autores principales: Miao, Hongming, Chen, Liang, Hao, Lijun, Zhang, Xuan, Chen, Yujuan, Ruan, Zhihua, Liang, Houjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536527/
https://www.ncbi.nlm.nih.gov/pubmed/26271607
http://dx.doi.org/10.1038/srep13092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536527/
https://www.ncbi.nlm.nih.gov/pubmed/26271607
http://dx.doi.org/10.1038/srep13092

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