High 24-Hour Urinary C-Peptide Excretion in Non-Insulin Dependent Diabetes Mellitus

The 24-hour urinary C-peptide excretion (UCPR) is a useful means of estimating total daily insulin secretion. To evaluate the daily insulin secretion rate in non-insulin dependent diabetes mellitus (NIDDM), we measured UCPR in 22 patients with NIDDM and 18 normal subjects. The mean (±SD) UCPR in the patients with NIDDM was 115.4±40.2 ug/day and that in normal subjects was 56.7±22.0 ug/day respectively with significantly higher values in the patients with NIDDM (P<0.0001). UCPR was positively correlated with body fat mass determined by measurement of skin fold thickness in both groups [r=0.51 in patients with NIDDM (n=22; p<0.02) and r=0.55 in normal subjects (n=18; p<0.02)], and was higher in NIDDM patients, even with the same degree of fat mass. There was no significant correlation between UCPR and body muscle mass both in the patients with NIDDM and normal subjects [r=0.16 in patients with NIDDM (n=22; p>0.1) and r=0.16 in normal subjects (n=18; p>0.1)]. This result suggested that the total daily insulin secretion rate in NIDDM be increased to compensate insulin resistance, especially that induced by adipose tissues.