Cargando…

Design of a randomized controlled trial of disclosing genomic risk of coronary heart disease: the Myocardial Infarction Genes (MI-GENES) study

BACKGROUND: Whether disclosure of a genetic risk score (GRS) for a common disease influences relevant clinical outcomes is unknown. We describe design of the Myocardial Infarction Genes (MI-GENES) Study, a randomized clinical trial to assess whether disclosing a GRS for coronary heart disease (CHD)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kullo, Iftikhar J., Jouni, Hayan, Olson, Janet E., Montori, Victor M., Bailey, Kent R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536729/ https://www.ncbi.nlm.nih.gov/pubmed/26271327 http://dx.doi.org/10.1186/s12920-015-0122-0

Ejemplares similares

Electronic health record access by patients as an indicator of information seeking and sharing for cardiovascular health promotion in social networks: Secondary analysis of a randomized clinical trial
por: Brown, Sherry-Ann N., et al.
Publicado: (2019)

Genotype-informed estimation of risk of coronary heart disease based on genome-wide association data linked to the electronic medical record
por: Ding, Keyue, et al.
Publicado: (2011)

A Genome-Wide Association Study of Red Blood Cell Traits Using the Electronic Medical Record
por: Kullo, Iftikhar J., et al.
Publicado: (2010)

Clinical Correlates of Autosomal Chromosomal Abnormalities in an Electronic Medical Record–Linked Genome-Wide Association Study: A Case Series
por: Jouni, Hayan, et al.
Publicado: (2013)

The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study
por: Kullo, Iftikhar J., et al.
Publicado: (2014)

Design of a Controlled Trial of Cascade Screening for Hypercholesterolemia: The (CASH) Study
por: Kullo, Iftikhar J., et al.
Publicado: (2018)

Coronary Heart Disease Risk Associated with Primary Isolated Hypertriglyceridemia; a Population‐Based Study
por: Saadatagah, Seyedmohammad, et al.
Publicado: (2021)

Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction
por: Maruyama, Kazuaki, et al.
Publicado: (2021)

The Usefulness of Assessing Heart Rate Variability in Patients with Acute Myocardial Infarction (HeaRt-V-AMI)
por: Brinza, Crischentian, et al.
Publicado: (2022)

Patterns of population differentiation of candidate genes for cardiovascular disease
por: Kullo, Iftikhar J, et al.
Publicado: (2007)

Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of tocilizumab on myocardial salvage in patients with acute ST-elevation myocardial infarction (STEMI)
por: Anstensrud, Anne Kristine, et al.
Publicado: (2019)

Effects of nicorandil on myocardial infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: study design and protocol for the randomized controlled trial
por: JIANG, Xiao-Si, et al.
Publicado: (2020)

Randomised controlled trial of a secondary prevention program for myocardial infarction patients ('ProActive Heart'): study protocol. Secondary prevention program for myocardial infarction patients
por: Hawkes, Anna L, et al.
Publicado: (2009)

Colchicine to Prevent Sympathetic Denervation after an Acute Myocardial Infarction: The COLD-MI Trial Protocol
por: Huet, Fabien, et al.
Publicado: (2021)

To disclose, or not to disclose? Context matters
por: Rahimzadeh, Vasiliki, et al.
Publicado: (2015)

Rapid use of high-sensitive cardiac troponin I for ruling-in and ruling-out of acute myocardial infarction (RACING-MI): study protocol
por: Bang, Camilla, et al.
Publicado: (2019)

Bioinformatic screening for key miRNAs and genes associated with myocardial infarction
por: Wu, Ke, et al.
Publicado: (2018)

Disclosing ambiguous gene aliases by automatic literature profiling
por: Coimbra, Roney S, et al.
Publicado: (2010)

Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)
por: Siddiqi, Nishat, et al.
Publicado: (2013)

Myocardial Infarction - Stress PRevention INTervention (MI-SPRINT) to reduce the incidence of posttraumatic stress after acute myocardial infarction through trauma-focused psychological counseling: study protocol for a randomized controlled trial
por: Meister, Rebecca, et al.
Publicado: (2013)

Billing code algorithms to identify cases of peripheral artery disease from administrative data
por: Fan, Jin, et al.
Publicado: (2013)

Recurrent ST-Elevation Myocardial Infarction (STEMI) in Coronary Artery Aneurysm Secondary to Atherosclerosis
por: Bhuiyan, Md, et al.
Publicado: (2022)

The biomarkers of key miRNAs and target genes associated with acute myocardial infarction
por: Wang, Qi, et al.
Publicado: (2020)

COMPUTED ALGORITHMS TO IDENTIFY SUBTYPES OF ACUTE MYOCARDIAL INJURY IN ACUTE COVID-19
por: Satterfield, Benjamin, et al.
Publicado: (2022)

The clinical effect of arrhythmia monitoring after myocardial infarction (BIO-GUARD|MI):study protocol for a randomized controlled trial
por: Jons, Christian, et al.
Publicado: (2019)

Integrin Beta-3 Gene Polymorphism and Risk for Myocardial Infarction in Premature Coronary Disease
por: Sheikhvatan, Mehrdad, et al.
Publicado: (2019)

Quality of life in patients with coronary heart disease after myocardial infarction and with ischemic heart failure
por: Moryś, Joanna M., et al.
Publicado: (2015)

Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing
por: Saad, Mohamad, et al.
Publicado: (2022)

Discovering Novel Biochemical and Genetic Markers for Coronary Heart Disease in Qatari Individuals: The Initiative Qatar Cardiovascular Biorepository
por: El-Menyar, Ayman, et al.
Publicado: (2020)

Inflammatory markers in acute myocardial infarction and the correlation with the severity of coronary heart disease
por: Oprescu, Nicoleta, et al.
Publicado: (2021)

Atrial Fibrillation With Decompensated Heart Failure Complicated With Non-ST Elevation Myocardial Infarction
por: Shaban, Eman E, et al.
Publicado: (2022)

Optimal strategy of primary percutaneous coronary intervention for acute myocardial infarction due to unprotected left main coronary artery occlusion (OPTIMAL): study protocol for a randomised controlled trial
por: Gao, Yang, et al.
Publicado: (2019)

Thyroxine in acute myocardial infarction (ThyrAMI) - levothyroxine in subclinical hypothyroidism post-acute myocardial infarction: study protocol for a randomised controlled trial
por: Jabbar, Avais, et al.
Publicado: (2015)

Disease Location Is Associated With Survival in Patients With Peripheral Arterial Disease
por: Chen, Qian, et al.
Publicado: (2013)

ST-segment elevation myocardial infarction heart of Charlotte one-year (STEMI HOC-1) study: a prospective study protocol
por: Badianyama, Marheb, et al.
Publicado: (2023)

Analysis of epicardial genes in embryonic mouse hearts with flow cytometry
por: Redpath, Andia Nicole, et al.
Publicado: (2021)

Traffic-Related Air Pollution and the Onset of Myocardial Infarction: Disclosing Benzene as a Trigger? A Small-Area Case-Crossover Study
por: Bard, Denis, et al.
Publicado: (2014)

Incidence of myocardial infarction in people with diabetes compared to those without diabetes: a systematic review protocol
por: Narres, Maria, et al.
Publicado: (2022)

Intra-coronary administration of tacrolimus markedly attenuates infarct size and preserves heart function in porcine myocardial infarction
por: Chua, Sarah, et al.
Publicado: (2012)

Construction of miRNA-mRNA network reveals crucial miRNAs and genes in acute myocardial infarction
por: Wang, Kai, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rv2fsjuaoi50igud2ob1h7getv