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Histone deacetylase inhibition protects hearing against acute ototoxicity by activating the Nf-κB pathway
Auditory hair cells have repeatedly been shown to be susceptible to ototoxicity from a multitude of drugs including aminoglycoside antibiotics. Here, we found that systemic HDAC inhibition using suberoylanilide hydroxamic acid (SAHA) on adult mice offers almost complete protection against hair cell...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536828/ https://www.ncbi.nlm.nih.gov/pubmed/26279947 http://dx.doi.org/10.1038/cddiscovery.2015.12 |