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Physical fitness, serum relaxin and duration of gestation
BACKGROUND: Women are recommended to perform regular exercise during pregnancy but the impact of physical fitness on duration of gestation and miscarriage is inconsistent. In addition, a dose-response relation between the amount of weekly exercise and increased risk of miscarriage in early pregnancy...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536895/ https://www.ncbi.nlm.nih.gov/pubmed/26272327 http://dx.doi.org/10.1186/s12884-015-0607-z |
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author | Thorell, Eva Goldsmith, Laura Weiss, Gerson Kristiansson, Per |
author_facet | Thorell, Eva Goldsmith, Laura Weiss, Gerson Kristiansson, Per |
author_sort | Thorell, Eva |
collection | PubMed |
description | BACKGROUND: Women are recommended to perform regular exercise during pregnancy but the impact of physical fitness on duration of gestation and miscarriage is inconsistent. In addition, a dose-response relation between the amount of weekly exercise and increased risk of miscarriage in early pregnancy has been observed. Previous studies have mostly used an epidemiologic method. Larger studies using careful measurement of physical fitness are needed. Besides physical fitness, maternal circulating concentrations of the hormone relaxin have been associated with decreased duration of gestation. METHODS: A prospective cohort including 20 women with miscarriage and 460 women with spontaneous onset of labour, recruited from maternal health care centres in central Sweden, were examined in early pregnancy regarding estimated absolute peak oxygen uptake ([Formula: see text] (peak, est.)) by cycle ergometer test, and maternal circulating serum relaxin concentrations. RESULTS: Women with miscarriage displayed the highest level of absolute [Formula: see text] (peak, est.) (2.61 l/min) and the lowest serum relaxin concentrations (640 ng/l). Among women with spontaneous onset of labour, the mean absolute [Formula: see text] (peak, est.) increased successively from the lowest estimated oxygen uptake of 2.31 l/min among those with preterm birth (n = 28), to an oxygen uptake of 2.49 l/min among women with postterm birth (n = 31). An opposite trend was shown regarding serum relaxin concentrations from women with miscarriage to those with postterm birth. Serum relaxin concentrations, but not absolute [Formula: see text] (peak, est.) was significantly and independently associated with duration of gestation in women with miscarriages, and absolute [Formula: see text] (peak, est.), age and multiple pregnancy were independently associated with duration of gestation in women with spontaneous onset of labour. CONCLUSIONS: Physical fitness appears to be a protective factor of established pregnancies and not significantly involved in the risk of early miscarriage. Additional studies are needed to more clearly define the role of relaxin in miscarriage. |
format | Online Article Text |
id | pubmed-4536895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45368952015-08-15 Physical fitness, serum relaxin and duration of gestation Thorell, Eva Goldsmith, Laura Weiss, Gerson Kristiansson, Per BMC Pregnancy Childbirth Research Article BACKGROUND: Women are recommended to perform regular exercise during pregnancy but the impact of physical fitness on duration of gestation and miscarriage is inconsistent. In addition, a dose-response relation between the amount of weekly exercise and increased risk of miscarriage in early pregnancy has been observed. Previous studies have mostly used an epidemiologic method. Larger studies using careful measurement of physical fitness are needed. Besides physical fitness, maternal circulating concentrations of the hormone relaxin have been associated with decreased duration of gestation. METHODS: A prospective cohort including 20 women with miscarriage and 460 women with spontaneous onset of labour, recruited from maternal health care centres in central Sweden, were examined in early pregnancy regarding estimated absolute peak oxygen uptake ([Formula: see text] (peak, est.)) by cycle ergometer test, and maternal circulating serum relaxin concentrations. RESULTS: Women with miscarriage displayed the highest level of absolute [Formula: see text] (peak, est.) (2.61 l/min) and the lowest serum relaxin concentrations (640 ng/l). Among women with spontaneous onset of labour, the mean absolute [Formula: see text] (peak, est.) increased successively from the lowest estimated oxygen uptake of 2.31 l/min among those with preterm birth (n = 28), to an oxygen uptake of 2.49 l/min among women with postterm birth (n = 31). An opposite trend was shown regarding serum relaxin concentrations from women with miscarriage to those with postterm birth. Serum relaxin concentrations, but not absolute [Formula: see text] (peak, est.) was significantly and independently associated with duration of gestation in women with miscarriages, and absolute [Formula: see text] (peak, est.), age and multiple pregnancy were independently associated with duration of gestation in women with spontaneous onset of labour. CONCLUSIONS: Physical fitness appears to be a protective factor of established pregnancies and not significantly involved in the risk of early miscarriage. Additional studies are needed to more clearly define the role of relaxin in miscarriage. BioMed Central 2015-08-14 /pmc/articles/PMC4536895/ /pubmed/26272327 http://dx.doi.org/10.1186/s12884-015-0607-z Text en © Thorell et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Thorell, Eva Goldsmith, Laura Weiss, Gerson Kristiansson, Per Physical fitness, serum relaxin and duration of gestation |
title | Physical fitness, serum relaxin and duration of gestation |
title_full | Physical fitness, serum relaxin and duration of gestation |
title_fullStr | Physical fitness, serum relaxin and duration of gestation |
title_full_unstemmed | Physical fitness, serum relaxin and duration of gestation |
title_short | Physical fitness, serum relaxin and duration of gestation |
title_sort | physical fitness, serum relaxin and duration of gestation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536895/ https://www.ncbi.nlm.nih.gov/pubmed/26272327 http://dx.doi.org/10.1186/s12884-015-0607-z |
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