Macrophage heterogeneity, phenotypes, and roles in renal fibrosis

Macrophages (MΦ) are highly heterogeneous cells that exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease type and stage. MΦ are distributed throughout normal and diseased kidney tissue, where they have been recognized as key factors in renal...

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Detalles Bibliográficos
Autores principales: Cao, Qi, Wang, Yiping, Harris, David C H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536959/
https://www.ncbi.nlm.nih.gov/pubmed/26312145
http://dx.doi.org/10.1038/kisup.2014.4
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author Cao, Qi
Wang, Yiping
Harris, David C H
author_facet Cao, Qi
Wang, Yiping
Harris, David C H
author_sort Cao, Qi
collection PubMed
description Macrophages (MΦ) are highly heterogeneous cells that exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease type and stage. MΦ are distributed throughout normal and diseased kidney tissue, where they have been recognized as key factors in renal fibrosis. Recent studies have identified switch of phenotype and diverse roles for MΦ in several murine models of kidney disease. In this review, we discuss macrophage heterogeneity and their involvement in renal fibrosis.
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spelling pubmed-45369592015-08-24 Macrophage heterogeneity, phenotypes, and roles in renal fibrosis Cao, Qi Wang, Yiping Harris, David C H Kidney Int Suppl (2011) Mini Review Macrophages (MΦ) are highly heterogeneous cells that exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease type and stage. MΦ are distributed throughout normal and diseased kidney tissue, where they have been recognized as key factors in renal fibrosis. Recent studies have identified switch of phenotype and diverse roles for MΦ in several murine models of kidney disease. In this review, we discuss macrophage heterogeneity and their involvement in renal fibrosis. Nature Publishing Group 2014-11 2014-10-31 /pmc/articles/PMC4536959/ /pubmed/26312145 http://dx.doi.org/10.1038/kisup.2014.4 Text en Copyright © 2014 International Society of Nephrology
spellingShingle Mini Review
Cao, Qi
Wang, Yiping
Harris, David C H
Macrophage heterogeneity, phenotypes, and roles in renal fibrosis
title Macrophage heterogeneity, phenotypes, and roles in renal fibrosis
title_full Macrophage heterogeneity, phenotypes, and roles in renal fibrosis
title_fullStr Macrophage heterogeneity, phenotypes, and roles in renal fibrosis
title_full_unstemmed Macrophage heterogeneity, phenotypes, and roles in renal fibrosis
title_short Macrophage heterogeneity, phenotypes, and roles in renal fibrosis
title_sort macrophage heterogeneity, phenotypes, and roles in renal fibrosis
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536959/
https://www.ncbi.nlm.nih.gov/pubmed/26312145
http://dx.doi.org/10.1038/kisup.2014.4
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