Deubiquitinases in cancer

Deubiquitinases are deubiquitinating enzymes (DUBs), which remove ubiquitin from proteins, thus regulating their proteasomal degradation, localization and activity. Here, we discuss DUBs as anti-cancer drug targets.

Detalles Bibliográficos
Autores principales: Wei, Rongbin, Liu, Xiaodong, Yu, Weixin, Yang, Tianshu, Cai, Wenping, Liu, Junjun, Huang, Xiao, Xu, Guo-tong, Zhao, Shouliang, Yang, Jianhua, Liu, Shangfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536986/
https://www.ncbi.nlm.nih.gov/pubmed/25972356
Descripción
Sumario:Deubiquitinases are deubiquitinating enzymes (DUBs), which remove ubiquitin from proteins, thus regulating their proteasomal degradation, localization and activity. Here, we discuss DUBs as anti-cancer drug targets.

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