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PI3K/AKT/mTOR pathway plays a major pathogenetic role in glycogen accumulation and tumor development in renal distal tubules of rats and men

Activation of the PI3K/AKT/mTOR pathway is a crucial molecular event in human clear cell renal cell carcinoma (ccRCC), and is also upregulated in diabetic nephropathy. In diabetic rats metabolic changes affect the renal distal tubular epithelium and lead to glycogen-storing Armanni-Ebstein lesions (...

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Detalles Bibliográficos
Autores principales:	Ribback, Silvia, Cigliano, Antonio, Kroeger, Nils, Pilo, Maria G., Terracciano, Luigi, Burchardt, Martin, Bannasch, Peter, Calvisi, Diego F., Dombrowski, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536997/ https://www.ncbi.nlm.nih.gov/pubmed/25948777

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