Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors

Histone deacetylases are important targets for cancer therapeutics, but their regulation is poorly understood. Our data show coordinated transcription of HDAC1 and HDAC2 in lung cancer cell lines, but suggest HDAC2 protein expression is cell-context specific. Through an unbiased siRNA screen we foun...

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Detalles Bibliográficos
Autores principales: Sacco, Joseph J., Kenyani, Jenna, Butt, Zohra, Carter, Rachel, Chew, Hui Yi, Cheeseman, Liam P., Darling, Sarah, Denny, Michael, Urbé, Sylvie, Clague, Michael J., Coulson, Judy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537048/
https://www.ncbi.nlm.nih.gov/pubmed/25970771

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