Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer

Hypoxia promotes neovascularization, increased tumor growth, and therapeutic resistance. The transcription factor, hypoxia-inducible factor 1α (HIF-1α), has been reported as the master driver of adaptation to hypoxia. We previously identified the sphingosine kinase 1/sphingosine 1-phosphate (SphK1/S...

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Detalles Bibliográficos
Autores principales: Ader, Isabelle, Gstalder, Cécile, Bouquerel, Pierre, Golzio, Muriel, Andrieu, Guillaume, Zalvidea, Santiago, Richard, Sylvain, Sabbadini, Roger A., Malavaud, Bernard, Cuvillier, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537051/
https://www.ncbi.nlm.nih.gov/pubmed/25915662

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