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Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila

The amyloid precursor protein (APP) plays a central role in Alzheimer’s disease (AD). APP can undergo two exclusive proteolytic pathways: cleavage by the α-secretase initiates the non-amyloidogenic pathway while cleavage by the β-secretase initiates the amyloidogenic pathway that leads, after a seco...

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Detalles Bibliográficos
Autores principales:	Bourdet, Isabelle, Lampin-Saint-Amaux, Aurélie, Preat, Thomas, Goguel, Valérie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537105/ https://www.ncbi.nlm.nih.gov/pubmed/26274614 http://dx.doi.org/10.1371/journal.pone.0135741

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