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Osteopontin Deficiency Accelerates Spontaneous Colitis in Mice with Disrupted Gut Microbiota and Macrophage Phagocytic Activity

BACKGROUND: Osteopontin (OPN) is a multifunctional protein expressed in a variety of tissues and cells. Recent studies revealed increased OPN expression in the inflamed intestinal tissues of patients with inflammatory bowel disease (IBD). The role of OPN in the pathophysiology of IBD, however, remai...

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Detalles Bibliográficos
Autores principales:	Toyonaga, Takahiko, Nakase, Hiroshi, Ueno, Satoru, Matsuura, Minoru, Yoshino, Takuya, Honzawa, Yusuke, Itou, Ayako, Namba, Kazuyoshi, Minami, Naoki, Yamada, Satoshi, Koshikawa, Yorimitsu, Uede, Toshimitsu, Chiba, Tsutomu, Okazaki, Kazuichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537118/ https://www.ncbi.nlm.nih.gov/pubmed/26274807 http://dx.doi.org/10.1371/journal.pone.0135552

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