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Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum Neurotoxin Serotype/A Inhibit Catalytic Activity

The paralytic disease botulism is caused by botulinum neurotoxins (BoNT), multi-domain proteins containing a zinc endopeptidase that cleaves the cognate SNARE protein, thereby blocking acetylcholine neurotransmitter release. Antitoxins currently used to treat botulism neutralize circulating BoNT but...

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Detalles Bibliográficos
Autores principales:	Fan, Yongfeng, Geren, Isin N., Dong, Jianbo, Lou, Jianlong, Wen, Weihua, Conrad, Fraser, Smith, Theresa J., Smith, Leonard A., Ho, Mengfei, Pires-Alves, Melissa, Wilson, Brenda A., Marks, James D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537209/ https://www.ncbi.nlm.nih.gov/pubmed/26275214 http://dx.doi.org/10.1371/journal.pone.0135306

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