Cargando…

Tetramethylpyrazine (TMP), an Active Ingredient of Chinese Herb Medicine Chuanxiong, Attenuates the Degeneration of Trabecular Meshwork through SDF-1/CXCR4 Axis

BACKGROUND: A traditional Chinese medicine, Tetramethylpyrazine (TMP), has been prescribed as a complementary treatment for glaucoma to improve patient prognosis. However, the pharmacological mechanism of action of TMP is poorly understood. In previous studies, we demonstrated that TMP exerts potent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Na, Zhang, Zhang, Chen, Pei, Zhong, Yimin, Cai, Xiaoxiao, Hu, Huan, Yang, Ying, Zhang, Jing, Li, Kaijing, Ge, Jian, Yu, Keming, Liu, Xing, Zhuang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537220/ https://www.ncbi.nlm.nih.gov/pubmed/26275042 http://dx.doi.org/10.1371/journal.pone.0133055

Ejemplares similares

Inhibition of Angiogenesis, Fibrosis and Thrombosis by Tetramethylpyrazine: Mechanisms Contributing to the SDF-1/CXCR4 Axis
por: Cai, Xiaoxiao, et al.
Publicado: (2014)

Tetramethylpyrazine-mediated regulation of CXCR4 in retinoblastoma is sensitive to cell density
por: Wu, Nandan, et al.
Publicado: (2017)

Tetramethylpyrazine-Inducible Promoter Region from Rhodococcus jostii TMP1
por: Stanislauskienė, Rūta, et al.
Publicado: (2018)

Human Trabecular Meshwork Progenitors
por: Zhu, Qin, et al.
Publicado: (2019)

Tetramethylpyrazine (TMP) protects rats against acute pancreatitis through NF-κB pathway
por: Chen, Longying, et al.
Publicado: (2019)

YAP and TAZ mediate steroid-induced alterations in the trabecular meshwork cytoskeleton in human trabecular meshwork cells
por: Peng, Jie, et al.
Publicado: (2018)

Homocysteine induces oxidative stress to damage trabecular meshwork cells
por: You, Zhi-Peng, et al.
Publicado: (2018)

Cardiovascular Actions and Therapeutic Potential of Tetramethylpyrazine (Active Component Isolated from Rhizoma Chuanxiong): Roles and Mechanisms
por: Guo, Ming, et al.
Publicado: (2016)

Activation of ATF4 triggers trabecular meshwork cell dysfunction and apoptosis in POAG
por: Ying, Ying, et al.
Publicado: (2021)

Phytochemical and Pharmacological Review of Da Chuanxiong Formula: A Famous Herb Pair Composed of Chuanxiong Rhizoma and Gastrodiae Rhizoma for Headache
por: Wang, Lu, et al.
Publicado: (2013)

Apoptosis in the trabecular meshwork of glaucomatous patients
por: Baleriola, Jimena, et al.
Publicado: (2008)

Two-photon imaging of the trabecular meshwork
por: Ammar, David A., et al.
Publicado: (2010)

Surgery on the Trabecular Meshwork: Histopathological Evidence
por: Bhartiya, Shibal, et al.
Publicado: (2015)

Oxidative stress and antioxidants in the trabecular meshwork
por: Wang, Mingxuan, et al.
Publicado: (2019)

Comparative Study of the Effects of Trabecular Meshwork Outflow Drugs on the Permeability and Nitric Oxide Production in Trabecular Meshwork Cells
por: Kim, Jae Woo
Publicado: (2017)

Age-Related Changes in Trabecular Meshwork Imaging
por: Gold, Mark E., et al.
Publicado: (2013)

An In-Depth View of the Porcine Trabecular Meshwork Proteome
por: Funke, Sebastian, et al.
Publicado: (2019)

Sampling trabecular meshwork using TrabEx+
por: Ramjiani, Vipul, et al.
Publicado: (2021)

Primary Human Trabecular Meshwork Model for Pseudoexfoliation
por: Chakraborty, Munmun, et al.
Publicado: (2021)

An Optimized Method to Decellularize Human Trabecular Meshwork
por: Crouch, Devon J., et al.
Publicado: (2022)

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway
por: Wang, Yiwen, et al.
Publicado: (2019)

Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration
por: Chen, Dong, et al.
Publicado: (2015)

Protein expression in human trabecular meshwork: downregulation of RhoGDI by dexamethasone in vitro
por: Yu, Minbin, et al.
Publicado: (2010)

Link between neurodegeneration and trabecular meshwork injury in glaucomatous patients
por: Zhang, Yong, et al.
Publicado: (2017)

Isolation and Expansion of Multipotent Progenitors from Human Trabecular Meshwork
por: Zhang, Yuan, et al.
Publicado: (2018)

High tetramethylpyrazine production by the endophytic bacterial Bacillus subtilis isolated from the traditional medicinal plant Ligusticum chuanxiong Hort.
por: Yin, D. D., et al.
Publicado: (2018)

Morphology of the Trabecular Meshwork and Schlemm's Canal in Posner-Schlossman Syndrome
por: Yan, Xiaoqin, et al.
Publicado: (2022)

Microstructure visualization of conventional outflow pathway and finite element modeling analysis of trabecular meshwork
por: Zhang, Jing, et al.
Publicado: (2016)

Effects of atorvastatin on porcine aqueous humour outflow and trabecular meshwork cells
por: Cong, Lin, et al.
Publicado: (2018)

Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma
por: Zhong, Yisheng, et al.
Publicado: (2013)

ETX1 is over-expressed in the glaucomatous trabecular meshwork
por: Iragavarapu, Saradha, et al.
Publicado: (2009)

Wnt gene expression in human trabecular meshwork cells
por: Shyam, Rajalekshmy, et al.
Publicado: (2010)

A20 Attenuates the Fibrotic Response in the Trabecular Meshwork
por: Mzyk, Philip, et al.
Publicado: (2022)

Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
por: Mzyk, Philip, et al.
Publicado: (2022)

Segmental outflow dynamics in the trabecular meshwork of living mice
por: Reina-Torres, Ester, et al.
Publicado: (2022)

Autophagy Mediates MMP-2 Expression in Glaucomatous Trabecular Meshwork Cells
por: Xiao, Yan-Ling, et al.
Publicado: (2022)

Author Correction: Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration
por: Chen, Dong, et al.
Publicado: (2022)

Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma
por: Sun, Hong, et al.
Publicado: (2019)

Dexamethasone Modulates the Dynamics of Wnt Signaling in Human Trabecular Meshwork Cells
por: Zhang, Chi, et al.
Publicado: (2023)

Inhibition of TGF-β2–Induced Trabecular Meshwork Fibrosis by Pirfenidone
por: Zhu, Xiaofeng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_b8l03bkq3jbg62qaulc4qdsjts