Binding Patterns of Rotavirus Genotypes P[4], P[6], and P[8] in China with Histo-Blood Group Antigens

Rotaviruses (RVs) are an important cause of severe gastroenteritis in children. It has been found that RV may recognize the histo-blood group antigens (HBGAs) as ligands or receptors and bind HBGAs in a type-dependent manner. In this study, we investigated the binding specificity of VP8* proteins fr...

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Detalles Bibliográficos
Autores principales: Ma, Xin, Li, Dan-di, Sun, Xiao-man, Guo, Yan-qing, Xiang, Jing-yao, Wang, Wei-huan, Zhang, Li-xia, Gu, Qing-jiu, Duan, Zhao-jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537235/
https://www.ncbi.nlm.nih.gov/pubmed/26274396
http://dx.doi.org/10.1371/journal.pone.0134584
Descripción
Sumario:Rotaviruses (RVs) are an important cause of severe gastroenteritis in children. It has been found that RV may recognize the histo-blood group antigens (HBGAs) as ligands or receptors and bind HBGAs in a type-dependent manner. In this study, we investigated the binding specificity of VP8* proteins from human rotaviruses (RV) that are prevalent in China including genotypes P[4], P[6], and P[8]. Through the saliva- and oligosaccharide-based binding assays, we found that the VP8* proteins of P[4] and P[8] RV showed similar reactivity with the Le(b) and H type 1 antigens, while P[6] RV weakly bound the Le(b) antigen. These findings may facilitate further research into RV host specificity and vaccine development.

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