Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model

Temporal lobe epilepsy (TLE) is the most common form of drug resistant epilepsy. Current treatment is symptomatic, suppressing seizures, but has no disease modifying effect on epileptogenesis. We examined the effects of Z944, a potent T-type calcium channel antagonist, as an anti-seizure agent and a...

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Detalles Bibliográficos
Autores principales: Casillas-Espinosa, Pablo Miguel, Hicks, Ashleigh, Jeffreys, Amy, Snutch, Terrance P., O’Brien, Terence J., Powell, Kim L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537250/
https://www.ncbi.nlm.nih.gov/pubmed/26274319
http://dx.doi.org/10.1371/journal.pone.0130012

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