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Age-associated increase of skin fibroblast-derived prostaglandin E(2) contributes to reduced collagen levels in elderly human skin

Production of type I collagen declines during aging, leading to skin thinning and impaired function. Prostaglandin E(2) (PGE(2)) is a pleiotropic lipid mediator that is synthesized from arachidonic acid by the sequential actions of cyclooxygenases (COX) and PGE synthases (PTGES). PGE(2) inhibits col...

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Detalles Bibliográficos
Autores principales:	Li, Yong, Lei, Dan, Swindell, William R, Xia, Wei, Weng, Shinuo, Fu, Jianping, Worthen, Christal A, Okubo, Toru, Johnston, Andrew, Gudjonsson, Johann E, Voorhees, John J, Fisher, Gary J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537382/ https://www.ncbi.nlm.nih.gov/pubmed/25905589 http://dx.doi.org/10.1038/jid.2015.157

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