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Functional metabolomics: from biomarker discovery to metabolome reprogramming

Metabolomics is emerging as a powerful tool for studying metabolic processes, identifying crucial biomarkers responsible for metabolic characteristics and revealing metabolic mechanisms, which construct the content of discovery metabolomics. The crucial biomarkers can be used to reprogram a metabolo...

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Detalles Bibliográficos
Autores principales: Peng, Bo, Li, Hui, Peng, Xuan-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537470/
https://www.ncbi.nlm.nih.gov/pubmed/26135925
http://dx.doi.org/10.1007/s13238-015-0185-x
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author Peng, Bo
Li, Hui
Peng, Xuan-Xian
author_facet Peng, Bo
Li, Hui
Peng, Xuan-Xian
author_sort Peng, Bo
collection PubMed
description Metabolomics is emerging as a powerful tool for studying metabolic processes, identifying crucial biomarkers responsible for metabolic characteristics and revealing metabolic mechanisms, which construct the content of discovery metabolomics. The crucial biomarkers can be used to reprogram a metabolome, leading to an aimed metabolic strategy to cope with alteration of internal and external environments, naming reprogramming metabolomics here. The striking feature on the similarity of the basic metabolic pathways and components among vastly different species makes the reprogramming metabolomics possible when the engineered metabolites play biological roles in cellular activity as a substrate of enzymes and a regulator to other molecules including proteins. The reprogramming metabolomics approach can be used to clarify metabolic mechanisms of responding to changed internal and external environmental factors and to establish a framework to develop targeted tools for dealing with the changes such as controlling and/or preventing infection with pathogens and enhancing host immunity against pathogens. This review introduces the current state and trends of discovery metabolomics and reprogramming metabolomics and highlights the importance of reprogramming metabolomics.
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spelling pubmed-45374702015-08-15 Functional metabolomics: from biomarker discovery to metabolome reprogramming Peng, Bo Li, Hui Peng, Xuan-Xian Protein Cell Review Metabolomics is emerging as a powerful tool for studying metabolic processes, identifying crucial biomarkers responsible for metabolic characteristics and revealing metabolic mechanisms, which construct the content of discovery metabolomics. The crucial biomarkers can be used to reprogram a metabolome, leading to an aimed metabolic strategy to cope with alteration of internal and external environments, naming reprogramming metabolomics here. The striking feature on the similarity of the basic metabolic pathways and components among vastly different species makes the reprogramming metabolomics possible when the engineered metabolites play biological roles in cellular activity as a substrate of enzymes and a regulator to other molecules including proteins. The reprogramming metabolomics approach can be used to clarify metabolic mechanisms of responding to changed internal and external environmental factors and to establish a framework to develop targeted tools for dealing with the changes such as controlling and/or preventing infection with pathogens and enhancing host immunity against pathogens. This review introduces the current state and trends of discovery metabolomics and reprogramming metabolomics and highlights the importance of reprogramming metabolomics. Higher Education Press 2015-07-02 2015-09 /pmc/articles/PMC4537470/ /pubmed/26135925 http://dx.doi.org/10.1007/s13238-015-0185-x Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Peng, Bo
Li, Hui
Peng, Xuan-Xian
Functional metabolomics: from biomarker discovery to metabolome reprogramming
title Functional metabolomics: from biomarker discovery to metabolome reprogramming
title_full Functional metabolomics: from biomarker discovery to metabolome reprogramming
title_fullStr Functional metabolomics: from biomarker discovery to metabolome reprogramming
title_full_unstemmed Functional metabolomics: from biomarker discovery to metabolome reprogramming
title_short Functional metabolomics: from biomarker discovery to metabolome reprogramming
title_sort functional metabolomics: from biomarker discovery to metabolome reprogramming
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537470/
https://www.ncbi.nlm.nih.gov/pubmed/26135925
http://dx.doi.org/10.1007/s13238-015-0185-x
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