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Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response

Interleukin-8 (IL-8) has been implicated in the pathogenesis of several human respiratory diseases, including tuberculosis (TB). Importantly and in direct relevance to the objectives of this report quite a few findings suggest that the presence of IL-8 may be beneficial for the host. IL-8 may aid wi...

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Autores principales: Krupa, Agnieszka, Fol, Marek, Dziadek, Bozena R., Kepka, Ewa, Wojciechowska, Dominika, Brzostek, Anna, Torzewska, Agnieszka, Dziadek, Jaroslaw, Baughman, Robert P., Griffith, David, Kurdowska, Anna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537748/
https://www.ncbi.nlm.nih.gov/pubmed/26300588
http://dx.doi.org/10.1155/2015/124762
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author Krupa, Agnieszka
Fol, Marek
Dziadek, Bozena R.
Kepka, Ewa
Wojciechowska, Dominika
Brzostek, Anna
Torzewska, Agnieszka
Dziadek, Jaroslaw
Baughman, Robert P.
Griffith, David
Kurdowska, Anna K.
author_facet Krupa, Agnieszka
Fol, Marek
Dziadek, Bozena R.
Kepka, Ewa
Wojciechowska, Dominika
Brzostek, Anna
Torzewska, Agnieszka
Dziadek, Jaroslaw
Baughman, Robert P.
Griffith, David
Kurdowska, Anna K.
author_sort Krupa, Agnieszka
collection PubMed
description Interleukin-8 (IL-8) has been implicated in the pathogenesis of several human respiratory diseases, including tuberculosis (TB). Importantly and in direct relevance to the objectives of this report quite a few findings suggest that the presence of IL-8 may be beneficial for the host. IL-8 may aid with mounting an adequate response during infection with Mycobacterium tuberculosis (M. tb); however, the underlying mechanism remains largely unknown. The major goal of our study was to investigate the contribution of IL-8 to the inflammatory processes that are typically elicited in patients with TB. We have shown for the first time that IL-8 can directly bind to tubercle bacilli. We have also demonstrated that association of IL-8 with M. tb molecules leads to the augmentation of the ability of leukocytes (neutrophils and macrophages) to phagocyte and kill these bacilli. In addition, we have shown that significant amount of IL-8 present in the blood of TB patients associates with erythrocytes. Finally, we have noted that IL-8 is the major chemokine responsible for recruiting T lymphocytes (CD3(+), CD4(+), and CD8(+) T cells). In summary, our data suggest that the association of IL-8 with M. tb molecules may modify and possibly enhance the innate immune response in patients with TB.
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spelling pubmed-45377482015-08-23 Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response Krupa, Agnieszka Fol, Marek Dziadek, Bozena R. Kepka, Ewa Wojciechowska, Dominika Brzostek, Anna Torzewska, Agnieszka Dziadek, Jaroslaw Baughman, Robert P. Griffith, David Kurdowska, Anna K. Mediators Inflamm Research Article Interleukin-8 (IL-8) has been implicated in the pathogenesis of several human respiratory diseases, including tuberculosis (TB). Importantly and in direct relevance to the objectives of this report quite a few findings suggest that the presence of IL-8 may be beneficial for the host. IL-8 may aid with mounting an adequate response during infection with Mycobacterium tuberculosis (M. tb); however, the underlying mechanism remains largely unknown. The major goal of our study was to investigate the contribution of IL-8 to the inflammatory processes that are typically elicited in patients with TB. We have shown for the first time that IL-8 can directly bind to tubercle bacilli. We have also demonstrated that association of IL-8 with M. tb molecules leads to the augmentation of the ability of leukocytes (neutrophils and macrophages) to phagocyte and kill these bacilli. In addition, we have shown that significant amount of IL-8 present in the blood of TB patients associates with erythrocytes. Finally, we have noted that IL-8 is the major chemokine responsible for recruiting T lymphocytes (CD3(+), CD4(+), and CD8(+) T cells). In summary, our data suggest that the association of IL-8 with M. tb molecules may modify and possibly enhance the innate immune response in patients with TB. Hindawi Publishing Corporation 2015 2015-08-02 /pmc/articles/PMC4537748/ /pubmed/26300588 http://dx.doi.org/10.1155/2015/124762 Text en Copyright © 2015 Agnieszka Krupa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Krupa, Agnieszka
Fol, Marek
Dziadek, Bozena R.
Kepka, Ewa
Wojciechowska, Dominika
Brzostek, Anna
Torzewska, Agnieszka
Dziadek, Jaroslaw
Baughman, Robert P.
Griffith, David
Kurdowska, Anna K.
Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response
title Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response
title_full Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response
title_fullStr Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response
title_full_unstemmed Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response
title_short Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response
title_sort binding of cxcl8/il-8 to mycobacterium tuberculosis modulates the innate immune response
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537748/
https://www.ncbi.nlm.nih.gov/pubmed/26300588
http://dx.doi.org/10.1155/2015/124762
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