Cytoplasmic p27 promotes epithelial–mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation

p27 restrains normal cell growth, but PI3K-dependent C-terminal phosphorylation of p27 at threonine 157 (T157) and T198 promotes cancer cell invasion. Here, we describe an oncogenic feedforward loop in which p27pT157pT198 binds Janus kinase 2 (JAK2) promoting STAT3 (signal transducer and activator o...

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Detalles Bibliográficos
Autores principales: Zhao, D, Besser, A H, Wander, S A, Sun, J, Zhou, W, Wang, B, Ince, T, Durante, M A, Guo, W, Mills, G, Theodorescu, D, Slingerland, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537852/
https://www.ncbi.nlm.nih.gov/pubmed/25684140
http://dx.doi.org/10.1038/onc.2014.473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537852/
https://www.ncbi.nlm.nih.gov/pubmed/25684140
http://dx.doi.org/10.1038/onc.2014.473

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