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Biological Roles of Resolvins and Related Substances in the Resolution of Pain
Endogenous pain-inhibitory substances have rarely been found. A group of powerful pain suppressor molecules that are endogenously generated are now emerging: resolvins and related compounds including neuroprotectins and maresins. These molecules began to be unveiled in a series of inflammation studi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538417/ https://www.ncbi.nlm.nih.gov/pubmed/26339646 http://dx.doi.org/10.1155/2015/830930 |
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author | Lim, Ji Yeon Park, Chul-Kyu Hwang, Sun Wook |
author_facet | Lim, Ji Yeon Park, Chul-Kyu Hwang, Sun Wook |
author_sort | Lim, Ji Yeon |
collection | PubMed |
description | Endogenous pain-inhibitory substances have rarely been found. A group of powerful pain suppressor molecules that are endogenously generated are now emerging: resolvins and related compounds including neuroprotectins and maresins. These molecules began to be unveiled in a series of inflammation studies more than a decade ago, rapidly shifting the paradigm that explains the mechanism for the inflammatory phase switch. The resolution phase was considered a passive process as proinflammatory mediators disappeared; it is now understood to be actively drawn by the actions of resolvins. Surprisingly, these substances potently affect the pain state. Although this research area is not fully matured, consistently beneficial outcomes have been observed in a various in vivo and in vitro pain models. Furthermore, multiple hypotheses on the neuronal and molecular mechanisms for alleviating pain are being tested, deriving inspiration from existing inflammation and pain studies. This paper serves as a brief summary of the proresolving roles of resolvins and related lipid mediators in inflammation and also as a review for accumulated information of their painkilling actions. This also includes potential receptor-mediated mechanisms and discusses future scientific perspectives. Further diverse approaches will help to construct a hidden axis of natural protection principles and establish proofs of concept for pain relief. |
format | Online Article Text |
id | pubmed-4538417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45384172015-09-03 Biological Roles of Resolvins and Related Substances in the Resolution of Pain Lim, Ji Yeon Park, Chul-Kyu Hwang, Sun Wook Biomed Res Int Review Article Endogenous pain-inhibitory substances have rarely been found. A group of powerful pain suppressor molecules that are endogenously generated are now emerging: resolvins and related compounds including neuroprotectins and maresins. These molecules began to be unveiled in a series of inflammation studies more than a decade ago, rapidly shifting the paradigm that explains the mechanism for the inflammatory phase switch. The resolution phase was considered a passive process as proinflammatory mediators disappeared; it is now understood to be actively drawn by the actions of resolvins. Surprisingly, these substances potently affect the pain state. Although this research area is not fully matured, consistently beneficial outcomes have been observed in a various in vivo and in vitro pain models. Furthermore, multiple hypotheses on the neuronal and molecular mechanisms for alleviating pain are being tested, deriving inspiration from existing inflammation and pain studies. This paper serves as a brief summary of the proresolving roles of resolvins and related lipid mediators in inflammation and also as a review for accumulated information of their painkilling actions. This also includes potential receptor-mediated mechanisms and discusses future scientific perspectives. Further diverse approaches will help to construct a hidden axis of natural protection principles and establish proofs of concept for pain relief. Hindawi Publishing Corporation 2015 2015-08-03 /pmc/articles/PMC4538417/ /pubmed/26339646 http://dx.doi.org/10.1155/2015/830930 Text en Copyright © 2015 Ji Yeon Lim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lim, Ji Yeon Park, Chul-Kyu Hwang, Sun Wook Biological Roles of Resolvins and Related Substances in the Resolution of Pain |
title | Biological Roles of Resolvins and Related Substances in the Resolution of Pain |
title_full | Biological Roles of Resolvins and Related Substances in the Resolution of Pain |
title_fullStr | Biological Roles of Resolvins and Related Substances in the Resolution of Pain |
title_full_unstemmed | Biological Roles of Resolvins and Related Substances in the Resolution of Pain |
title_short | Biological Roles of Resolvins and Related Substances in the Resolution of Pain |
title_sort | biological roles of resolvins and related substances in the resolution of pain |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538417/ https://www.ncbi.nlm.nih.gov/pubmed/26339646 http://dx.doi.org/10.1155/2015/830930 |
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