Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism

[Image: see text] We employ glass microtube structures fabricated by rolled-up nanotechnology to infer the influence of scaffold dimensionality and cell confinement on neural stem cell (NSC) migration. Thereby, we observe a pronounced morphology change that marks a reversible mesenchymal to amoeboid...

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Autores principales: Koch, Britta, Meyer, Anne K., Helbig, Linda, Harazim, Stefan M., Storch, Alexander, Sanchez, Samuel, Schmidt, Oliver G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538455/
https://www.ncbi.nlm.nih.gov/pubmed/26161791
http://dx.doi.org/10.1021/acs.nanolett.5b02099
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author Koch, Britta
Meyer, Anne K.
Helbig, Linda
Harazim, Stefan M.
Storch, Alexander
Sanchez, Samuel
Schmidt, Oliver G.
author_facet Koch, Britta
Meyer, Anne K.
Helbig, Linda
Harazim, Stefan M.
Storch, Alexander
Sanchez, Samuel
Schmidt, Oliver G.
author_sort Koch, Britta
collection PubMed
description [Image: see text] We employ glass microtube structures fabricated by rolled-up nanotechnology to infer the influence of scaffold dimensionality and cell confinement on neural stem cell (NSC) migration. Thereby, we observe a pronounced morphology change that marks a reversible mesenchymal to amoeboid migration mode transition. Space restrictions preset by the diameter of nanomembrane topography modify the cell shape toward characteristics found in living tissue. We demonstrate the importance of substrate dimensionality for the migration mode of NSCs and thereby define rolled-up nanomembranes as the ultimate tool for single-cell migration studies.
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spelling pubmed-45384552015-08-18 Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism Koch, Britta Meyer, Anne K. Helbig, Linda Harazim, Stefan M. Storch, Alexander Sanchez, Samuel Schmidt, Oliver G. Nano Lett [Image: see text] We employ glass microtube structures fabricated by rolled-up nanotechnology to infer the influence of scaffold dimensionality and cell confinement on neural stem cell (NSC) migration. Thereby, we observe a pronounced morphology change that marks a reversible mesenchymal to amoeboid migration mode transition. Space restrictions preset by the diameter of nanomembrane topography modify the cell shape toward characteristics found in living tissue. We demonstrate the importance of substrate dimensionality for the migration mode of NSCs and thereby define rolled-up nanomembranes as the ultimate tool for single-cell migration studies. American Chemical Society 2015-07-10 2015-08-12 /pmc/articles/PMC4538455/ /pubmed/26161791 http://dx.doi.org/10.1021/acs.nanolett.5b02099 Text en Copyright © 2015 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Koch, Britta
Meyer, Anne K.
Helbig, Linda
Harazim, Stefan M.
Storch, Alexander
Sanchez, Samuel
Schmidt, Oliver G.
Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism
title Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism
title_full Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism
title_fullStr Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism
title_full_unstemmed Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism
title_short Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism
title_sort dimensionality of rolled-up nanomembranes controls neural stem cell migration mechanism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538455/
https://www.ncbi.nlm.nih.gov/pubmed/26161791
http://dx.doi.org/10.1021/acs.nanolett.5b02099
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