In Silico-Based High-Throughput Screen for Discovery of Novel Combinations for Tuberculosis Treatment

There are currently 18 drug classes for the treatment of tuberculosis, including those in the development pipeline. An in silico simulation enabled combing the innumerably large search space to derive multidrug combinations. Through the use of ordinary differential equations (ODE), we constructed an...

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Detalles Bibliográficos
Autores principales: Singh, Ragini, Ramachandran, Vasanthi, Shandil, Radha, Sharma, Sreevalli, Khandelwal, Swati, Karmarkar, Malancha, Kumar, Naveen, Solapure, Suresh, Saralaya, Ramanatha, Nanduri, Robert, Panduga, Vijender, Reddy, Jitendar, Prabhakar, K. R., Rajagopalan, Swaminathan, Rao, Narasimha, Narayanan, Shridhar, Anandkumar, Anand, Balasubramanian, V., Datta, Santanu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538536/
https://www.ncbi.nlm.nih.gov/pubmed/26149995
http://dx.doi.org/10.1128/AAC.05148-14

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