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Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cells

Moyamoya disease (MMD) is a cerebrovascular disorder characterized by occlusive lesions of the circle of Willis. To date, both environmental and genetic factors have been implicated for pathogenesis of MMD. Allelic variations in RNF213 are known to confer the risk of MMD; however, functional roles o...

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Detalles Bibliográficos
Autores principales: Ohkubo, Kazuhiro, Sakai, Yasunari, Inoue, Hirosuke, Akamine, Satoshi, Ishizaki, Yoshito, Matsushita, Yuki, Sanefuji, Masafumi, Torisu, Hiroyuki, Ihara, Kenji, Sardiello, Marco, Hara, Toshiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538604/
https://www.ncbi.nlm.nih.gov/pubmed/26278786
http://dx.doi.org/10.1038/srep13191