Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother–infant pairs

A precise biological mechanism by which cadmium acts as a developmental toxicant is unknown but is suggested to include an epigenetic basis. In prior work, we analyzed CpG island methylation levels within gene promoters (n = 16,421) in leukocytes collected from mothers and their infants from a pregn...

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Autores principales: Gona, Saideep, Sanders, Alison P., Miranda, Marie Lynn, Fry, Rebecca C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data in Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538703/
https://www.ncbi.nlm.nih.gov/pubmed/26295018
http://dx.doi.org/10.1016/j.gdata.2015.07.001
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author Gona, Saideep
Sanders, Alison P.
Miranda, Marie Lynn
Fry, Rebecca C.
author_facet Gona, Saideep
Sanders, Alison P.
Miranda, Marie Lynn
Fry, Rebecca C.
author_sort Gona, Saideep
collection PubMed
description A precise biological mechanism by which cadmium acts as a developmental toxicant is unknown but is suggested to include an epigenetic basis. In prior work, we analyzed CpG island methylation levels within gene promoters (n = 16,421) in leukocytes collected from mothers and their infants from a pregnancy cohort in Durham County, North Carolina. The CpG methylation levels were examined in relationship to prenatal exposure to cadmium and/or cotinine to identify genes and pathways influenced by in utero exposure. In the present article, we provide an enhanced description of the data collection and processing to facilitate cross-study comparisons. Data are available within the Gene Expression Omnibus database (GSE67976).
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spelling pubmed-45387032015-10-19 Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother–infant pairs Gona, Saideep Sanders, Alison P. Miranda, Marie Lynn Fry, Rebecca C. Genom Data Data in Brief A precise biological mechanism by which cadmium acts as a developmental toxicant is unknown but is suggested to include an epigenetic basis. In prior work, we analyzed CpG island methylation levels within gene promoters (n = 16,421) in leukocytes collected from mothers and their infants from a pregnancy cohort in Durham County, North Carolina. The CpG methylation levels were examined in relationship to prenatal exposure to cadmium and/or cotinine to identify genes and pathways influenced by in utero exposure. In the present article, we provide an enhanced description of the data collection and processing to facilitate cross-study comparisons. Data are available within the Gene Expression Omnibus database (GSE67976). Elsevier 2015-07-11 /pmc/articles/PMC4538703/ /pubmed/26295018 http://dx.doi.org/10.1016/j.gdata.2015.07.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Data in Brief
Gona, Saideep
Sanders, Alison P.
Miranda, Marie Lynn
Fry, Rebecca C.
Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother–infant pairs
title Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother–infant pairs
title_full Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother–infant pairs
title_fullStr Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother–infant pairs
title_full_unstemmed Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother–infant pairs
title_short Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother–infant pairs
title_sort prenatal exposure to cadmium and cotinine and cpg island dna methylation in mother–infant pairs
topic Data in Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538703/
https://www.ncbi.nlm.nih.gov/pubmed/26295018
http://dx.doi.org/10.1016/j.gdata.2015.07.001
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