p27(Kip1) and p21(Cip1) collaborate in the regulation of transcription by recruiting cyclin–Cdk complexes on the promoters of target genes

Transcriptional repressor complexes containing p130 and E2F4 regulate the expression of genes involved in DNA replication. During the G(1) phase of the cell cycle, sequential phosphorylation of p130 by cyclin-dependent kinases (Cdks) disrupts these complexes allowing gene expression. The Cdk inhibit...

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Detalles Bibliográficos
Autores principales: Orlando, Serena, Gallastegui, Edurne, Besson, Arnaud, Abril, Gabriel, Aligué, Rosa, Pujol, Maria Jesus, Bachs, Oriol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538812/
https://www.ncbi.nlm.nih.gov/pubmed/26071952
http://dx.doi.org/10.1093/nar/gkv593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538812/
https://www.ncbi.nlm.nih.gov/pubmed/26071952
http://dx.doi.org/10.1093/nar/gkv593

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