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p27(Kip1) and p21(Cip1) collaborate in the regulation of transcription by recruiting cyclin–Cdk complexes on the promoters of target genes
Transcriptional repressor complexes containing p130 and E2F4 regulate the expression of genes involved in DNA replication. During the G(1) phase of the cell cycle, sequential phosphorylation of p130 by cyclin-dependent kinases (Cdks) disrupts these complexes allowing gene expression. The Cdk inhibit...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538812/ https://www.ncbi.nlm.nih.gov/pubmed/26071952 http://dx.doi.org/10.1093/nar/gkv593 |