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The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80

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The faithful repair of DNA double-strand breaks (DSBs) is essential to safeguard genome stability. DSBs elicit a signaling cascade involving the E3 ubiquitin ligases RNF8/RNF168 and the ubiquitin-dependent assembly of the BRCA1-Abraxas-RAP80-MERIT40 complex. The association of BRCA1 with ubiquitin c...

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Detalles Bibliográficos
Autores principales:	Typas, Dimitris, Luijsterburg, Martijn S., Wiegant, Wouter W., Diakatou, Michaela, Helfricht, Angela, Thijssen, Peter E., van de Broek, Bram, Mullenders, Leon H., van Attikum, Haico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538816/ https://www.ncbi.nlm.nih.gov/pubmed/26101254 http://dx.doi.org/10.1093/nar/gkv613

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